p62蛋白在鼻咽癌组织中的表达及临床意义  

Expression of p62 protein in nasopharyngeal carcinoma and its clinical significance

作　　者：吴琼[1] 陈贞[1] 王堃[1] 向满林 易斌[1] 

机构地区：[1]中南大学湘雅医院检验科,长沙410008

出　　处：《中国医师杂志》2016年第2期216-219,223,共5页Journal of Chinese Physician

基　　金：2015年中南大学硕士生自主探索创新项目（2015zzts301）

摘　　要：目的研究p62蛋白在鼻咽癌（NPC）患者癌组织中的表达水平与鼻咽癌发生及转移之间的关系。方法应用免疫组织化学染色检测123例鼻咽癌患者和30例慢性鼻咽炎患者病变组织中p62蛋白表达水平，并分析其与临床病理特征的关系。结果p62蛋白在慢性鼻咽炎鼻咽组织、未转移NPC组织、转移NPC组织中阳性表达率分别为13．3％，66．67％，84．72％，差异有统计学意义（P〈0．01）。p62表达水平与NPC发生和转移有关，伴淋巴结转移或远处转移鼻咽癌患者p62蛋白表达水平显著高于无转移患者（P〈0．01或P〈0．05）。但p62表达水平与患者年龄、性别、原发灶大小及临床分期无关（P〉0．05）。结论鼻咽癌组织中p62蛋白高表达与鼻咽癌发生及转移密切相关，对鼻咽癌恶性程度及侵袭转移能力的预测评估有较好的参考价值。Objective To investigate the relationship between p62 expression, and occurrence and metastasis of nasopharyngeal carcinomas. Methods Immunohistochemical method was used to analyze p62 expression in 123 nasopharyngeal carcinoma （NPC） cases and 30 chronic nasopharyngitis cases. The clinical pathological characteristics were analyzed. Results The positive rate of p62 protein in chronic nasopharyngitis nasopharyngeal epithelium, non-metastatic NPC tissue, and metastatic NPC tissues was 13.3%, 66. 67%, and 84. 72%, respectively, and the difference was statistically significant. The expression of p62 protein in nasopharyngeal carcinoma patients with lymph node metastasis or distant metastasis was significantly higher than non-metastatic NPC patients （ P 〈0. 01 orP 〈0. 05）. However, the expression of 1362 was not related to age, gender, tumor size, and TNM stage （ P 〉 0.05）. Conclusions High p62 protein expression in nasopharyngeal carcinoma tissue is closely related to the occurrence and metastasis of nasopha ryngeal carcinomas. It provides good reference value to predict NPC malignancy and metastases.

关 键 词：原癌基因蛋白质c—myc/生物合成 鼻咽肿瘤/代谢 

分 类 号：R739.63[医药卫生—肿瘤]