新疆313例维汉老年胰腺癌患者预后分析  

Prognostic analysis of 313 aged pancreatic cancer patients in hospital treatment between Uygnr and Han nationality in Xinjiang area

作　　者：裴磊[1] 才层[1] 毛睿[1] 艾力江·吐尔逊[1] 赵化荣[1] 张华[1] 包永星[1] 

机构地区：[1]新疆医科大学第一附属医院肿瘤中心,乌鲁木齐830054

出　　处：《实用肿瘤学杂志》2016年第1期1-6,共6页Practical Oncology Journal

基　　金：乌鲁木齐市科技局项目（y141310033）

摘　　要：目的探讨影响新疆维汉老年胰腺癌患者（〉160岁）生存时间的预后因素。方法对本院2003年1月1日—2015年5月30日资料完整的313例老年胰腺癌患者进行回顾性研究。采用Kaplan—Meier法计算生存率，Log—rank检验影响预后的单因素分析，符合条件的纳入Cox比例风险模型进行多因素分析。结果313例老年胰腺癌患者中位生存时间为157天，0．5、1、2年生存率分别为34．8％、18．5％、7．O％。其中维汉两民族之间生存时间具有统计学差异（P〈0．001）。单因素分析显示，民族、ECOG评分（ZPS）、临床分期（TNM）、肿瘤大小、肿瘤部位、是否行手术治疗及行根治性手术、放化疗、治疗前CEA水平、CAl99水平与胰腺癌患者的长期生存有关，Cox多因素分析则显示，临床分期、手术治疗及手术方式可作为独立影响预后因素（P〈O．05）。结论临床分期（TNM）、手术治疗及手术方式可作为胰腺癌预后独立因素。无论汉族还是维吾尔族老年患者，及早地发现及及早行根治性手术是目前延长老年胰腺癌患者生存时间的关键。Objective To investigate the prognostic factors of survival time of the Uygur and Han nation- ality elderly patients（ over 60 years） with pancreatic cancer in Xinjiang. Methods We carried on a retrospective study of 313 aged patients diagnosed with pancreatic cancer in The First Affiliated Hospital of Xinjiang Medical University from January 1 st,2003 to May 30th ,2015. We used Kpalan - Meier method for calculation of survival, used Log - rank method for those factors which could affect the prognosis of patients, at last we used Cox propor- tional risk model for those multiple factors which match the role. Results Three hundred and thirteen cases with pancreatic cancer had a median survival of 157 days,and survival rates of half a year, 1 and 2 year were 34.8%, 18.5% ,7.0%. There was a statistic difference between Uygnr patients＇ and Han patients＇ survival time （P 〈 0.05 ）. Single factor analysis showed the nationality, tumor size, surgery, ZPS （ ECOG）, Clinical stage （ TNM ）, chemotherapy and radiotherapy ,carcino - embryonic antigen （CEA） level and cancer antigen 199 （ CA199 ） level before treatment with outcome （ P 〈 0.05 ）. Multiple factor analysis showed that the clinical stage, surgery （ P 〈 0.05） can be regarded as independent prognostic decision factors. Conclusion The clinical staging, surgical treatment could be regarded as independent prognostic factors for the elderly prognosis of pancreatic cancer. Both of the Hart and Uygnr patients, earlier discovered and more appropriate surgery treatment are the key for the elderly patients with pancreatic cancer.

关 键 词：胰腺癌 老年 预后 单因素分析 多因素分析 

分 类 号：R735.9[医药卫生—肿瘤]