大脑胰岛素信号通路与葡萄糖代谢在阿尔茨海默病中的作用与关系  

Insulin signaling pathway and glucose metabolism in Alzheimer′s diseases

作　　者：李栋[1] 黄晏[1] 周文霞[1] 张永祥[1] 

机构地区：[1]军事医学科学院毒物药物研究所、中药和神经免疫药理研究室、抗毒药物与毒理学国家重点实验室,北京100850

出　　处：《国际药学研究杂志》2016年第1期26-32,共7页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81202505;81302759)

摘　　要：阿尔茨海默病(Alzheimer′s diseases,AD)是一种缓慢发展的神经退行性疾病,尽管对AD的研究已达百余年,但其确切的发病机制尚不清楚,也缺乏有效的治疗药物。近几十年研究发现,AD患者伴随着大脑胰岛素信号通路障碍以及大脑葡萄糖代谢紊乱。因此,有研究者认为胰岛素信号通路及大脑葡萄糖代谢稳态在AD中起着重要作用,甚至有提出AD是"3型糖尿病"的假说。本文将着重讨论大脑内胰岛素信号通路、葡萄糖代谢过程以及二者与AD的关系,以及基于胰岛素通路的AD防治药物的研究进展。Alzheimer＇s disease （AD） is a degenerative metabolic disease, whose exact pathological mechanism still remains unknown. Currently, studies have found that patients in AD accompany with insulin signaling pathway impairment and cerebral glu- cose metabolism dysfunction. As insulin signaling pathway and cerebral glucose metabolism homeostasis play a key role in AD, some researches consider AD as ＂type Ⅲ diabetes＂. This review aims to discuss the alteration of cerebral insulin signaling pathway and glu- cose metabolism in AD, as well as their relationship with AD. We will also elaborate the advance in anti-AD drugs based on cerebral insulin signaling pathway.

关 键 词：阿尔茨海默病 胰岛素信号通路 葡萄糖代谢 葡萄糖转运 

分 类 号：R749.16[医药卫生—神经病学与精神病学]