黄体生成素在阿尔茨海默病发病机制中的作用  

Contribution of luteinizing hormone to Alzheimer′s disease

作　　者：王健辉[1] 程肖蕊[1] 周文霞[1] 张永祥[1] 

机构地区：[1]军事医学科学院毒物药物研究所、抗毒药物与毒理学国家重点实验室立,北京100850

出　　处：《国际药学研究杂志》2016年第1期50-55,共6页Journal of International Pharmaceutical Research

基　　金：国家“重大新药创制”科技重大专项资助项目(2013ZX09508104);国家自然科学基金面上项目(81473191)

摘　　要：黄体生成素(LH)位于下丘脑-垂体-性腺(HPG)轴的中游,其主要功能是刺激性腺分泌性激素。LH的分泌水平会随着机体的老化而逐步升高,而阿尔茨海默病(AD)患者体内的LH水平会异常升高。异常升高的LH在AD发病过程中处于相对关键的地位,并能加重认知功能的增龄性下降。为了更为全面深入的理解LH与AD的关系,本文主要对LH与AD的流行病学研究、认知损伤、病理特征以及LH受体之间的相关研究进行综述。Luteinizing hormone （LH） is a gonadotropin of hypothalamic-pituitary-gonadal axis （HPG）, secreted by the anteri- or pituitary. The secretion of LH is directly controlled by the release of gonadotropin releasing hormone （GnRH）, acts at the ovaries and testes to stimulate the production of gonadal hormones. Aging leads to increases in LH, and higher serum levels of LH has been ob- served in Alzheimer＇s disease（AD） patients when compared to age-matched controls. Evidences from basic research and epidemiologi- cal investigation support the critical role of elevated LH in pathogenic process of AD and deteriorating cognitive decline. Here we sum- marize the recent discoveries containing human AD epidemiological evidence for LH, cognitive impairments resulting from LH activi- ty, LH in AD pathology and LH receptor signaling mechanisms.

关 键 词：阿尔茨海默病 黄体生成素 认知 老化 性激素 

分 类 号：R749.16[医药卫生—神经病学与精神病学]