精神分裂症急性期患者5-羟色胺转运体mRNA表达相关因素分析  

Related factor analysis of serotonin transporter mRNA expression in schizophrenic patients at acute phase

作　　者：胡昌清[1,2] 丰雷 陈静 杨杨[1] 史晓宁[1] 田腾飞[1] 甄龙[1] 王刚 

机构地区：[1]首都医科大学附属北京安定医院抑郁症治疗中心,100088 [2]国家精神心理疾病临床医学研究中心 [3]精神疾病诊断与治疗北京市重点实验室 [4]北京市怀柔安佳医院医务科 [5]北京脑重大疾病研究院抑郁症研究所

出　　处：《临床精神医学杂志》2016年第1期1-3,共3页Journal of Clinical Psychiatry

基　　金：重大新药创制科技重大专项-精神疾病的新药临床评价研究技术平台建设(2012ZX09303014-002);国家自然科学基金面上项目(81171269);北京市教委面上项目(SQKM201210025021)

摘　　要：目的:探讨精神分裂症急性期患者5-羟色胺转运体(SERT)mRNA表达水平及其与临床因素的关系。方法:收集44例未经治疗的精神分裂症急性期患者的临床资料,给予阳性与阴性症状量表(PANSS)评估;采用逆转录聚合酶链反应(RT-PCR)方法测定外周血SERT mRNA表达。结果:有攻击行为患者(26例)SERT mRNA表达明显高于无攻击行为患者(18例)(F=9.75,P<0.01)。SERT mRNA表达与患者发病年龄无相关(r=0.056,P=0.722);与病程呈正相关(r=0.418,P<0.01);与PANSS的阴性症状分呈负相关(r=-0.335,P<0.05);与PANSS总分、阳性症状分及一般精神病理分无相关性(r=-0.156,P=0.317;r=0.115,P=0.465;r=-0.097,P=0.538)。结论:精神分裂症急性期患者SERT mRNA高表达与其病程长、伴有攻击行为以及阴性症状量表评分低有关。Objective： To explore the correlations between serotonin transporter （SERT） mRNA expres- sion and clinical factors in schizophrenic patients at acute phase. Method：The clinical data of 44 untreated schizophrenic patients at acute phase were collected; and they were assessed by positive and negative syndromes scales （PANSS） ; the expression of SERT mRNA of peripheral blood was detected by reverse transcriptase poly- merase chain reaction （RT-PCR）. Results：The expression of SERT mRNA in the patients with aggressive be- havior （26 cases） was significantly higher than the patients without aggressive behavior （ 18 cases） （ F =9. 75, P 〈 0.01 ）. The expression of SERT mRNA was not correlated with age of onset （ r = 0. 056 ,P = 0. 722 ）, posi- tively correlated with the course of disease （r = 0. 418, P 〈 0.01 ） ; negatively correlated with negative symptom score of PANSS（ r = - 0. 335,P 〈 0.05 ）, but not correlated with the total score of PANSS, scores of positive symptoms and general psychopathology （r = -0. 156,P =0. 317;r =0. I15,P =0. 465;r = -0.097,P = 0. 538 ）. Conclusion： The high expression of SERT mRNA in schizophrenic patients at acute phase is asso- ciated with longer duration, aggressive behavior and lower seore of negative symptoms scale.

关 键 词：精神分裂症 5-羟色胺转运体 MRNA表达 

分 类 号：R749.3[医药卫生—神经病学与精神病学]