子宫内膜癌组织中GDF-15、p-mTOR蛋白的表达及相关性  

Expression and correlation between GDF-15 and p-mTOR in endometrial carcinoma

作　　者：蔡东阁[1] 苏文秀[2] 赵晓桂[1] 闫桂花[1] 李牧[1] 

机构地区：[1]西安交通大学医学院第二附属医院妇产科,陕西西安710004 [2]西安交通大学医学院第二附属医院病理科,陕西西安710004

出　　处：《现代肿瘤医学》2016年第7期1110-1114,共5页Journal of Modern Oncology

基　　金：西安市科技局社会发展研究项目[编号:SF1510(1)]

摘　　要：目的:研究GDF-15和p-mT OR蛋白在子宫内膜癌组织中的表达及其与临床生物学特点的相关性,并分析恶性肿瘤发生发展和转移的内在信号通路。方法:免疫组织化学方法检测GDF-15和p-mT OR蛋白在65例子宫内膜癌和65例正常子宫内膜组织中的表达。结果:GDF-15和p-mT OR蛋白在子宫内膜癌组织中的表达率均明显高于对照组,差异有显著性意义(P<0.01)。GDF-15蛋白在Ⅰ-Ⅱ期子宫内膜癌组织中的表达率为52.94%,Ⅲ-Ⅳ期中的表达率为90.32%,两者比较有显著性差异(P<0.01)。GDF-15在癌灶肌层浸润深度≥1/2中表达率为92.00%,在癌灶肌层浸润深度<1/2组的表达率为57.50%(P<0.01)。GDF-15在存在肿瘤淋巴结转移的表达率为85.71%,无淋巴结转移的表达率为59.46%,两者相比有显著性差异(P=0.02)。p-mT OR蛋白在Ⅰ-Ⅱ期子宫内膜癌组织中的表达率为64.71%,Ⅲ-Ⅳ期中的表达率为93.55%,两者比较有显著性差异(P<0.01);p-mT OR在癌灶肌层浸润深度≥1/2中表达率为92.00%,在癌灶肌层浸润深度<1/2组的表达率为70.00%,两者相比有显著性差异(P<0.05)。pmT OR在存在肿瘤淋巴结转移的表达率为92.86%,无淋巴结转移的表达率为67.57%,两者相比有显著性差异(P<0.05)。GDF-15、p-mT OR的表达与患者的发病年龄、组织病理学分级无关(P>0.05)。子宫内膜癌组织中GDF-15和mT OR蛋白表达呈显著正相关(r=0.322,P<0.01)。结论:p-mT OR在子宫内膜癌中的表达受升高的GDF-15蛋白水平的调控,可能为子宫内膜癌发生发展及侵袭转移的重要信号转导通路。Objective： To study the expression of GDF- 15 and p- m TOR protein and the relationship with the pathogenesis and development of endometrial cancer so as to elucidate the role of m TOR signal transductive pathway.Methods： The expression of GDF- 15 and p- m TOR protein was detected in 65 endometrial cancer and 65 normal endometrial tissues with immunohistochemistry. Results： The positive expression rates of GDF- 15 and p- m TOR protein in endometrial carcinoma tissue were significantly higher than those in the normal endometrial tissue one＇s respectively（ P〈0. 01）. The positive rates of GDF- 15 and p- m TOR protein were significantly higher in endometrial carcinoma with muscle invasive depth 1 /2 muscular layer than in that 1 /2 muscular layer（ 92. 00% vs 57. 50%,92. 00% vs 70. 00% respectively）,higher in Ⅲ or higher FIGO stages than in Ⅰor Ⅱstages（ 90. 32% vs 52. 94%,93. 55% vs 64. 71% respectively）,higher in patients with lymph node metastasis than in those without（ 85. 71% vs59. 46%,92. 86% vs 67. 57% respectively）. The positive expression of GDF- 15 and p- m TOR was not associated with age or differentiation degree（ P〉0. 05）. GDF- 15 positive cases were significantly positively correlated with p-m TOR positive cases（ r = 0. 322,P〈0. 01）. Conclusion： GDF- 15 can promote p- m TOR in the process of pathogenesis and development in endometrial carcinoma and they maybe the important signal transduction pathway.

关 键 词：子宫内膜癌 生长分化因子15 磷酸化雷帕霉素靶蛋白 

分 类 号：R737.33[医药卫生—肿瘤]