CIK细胞免疫治疗晚期消化系统恶性肿瘤的临床疗效评价  

Clinical efficacy of CIK cells in the treatment of advanced digestive system malignant tumor

作　　者：罗云秀 罗仁峰[2] 何安兵 彭秀兰 王群 刘爱华 李晓光 童文先 田倩 王虎 龙志雄 

机构地区：[1]武汉市第五医院,湖北武汉430050 [2]江汉大学医学院,湖北武汉430050

出　　处：《现代肿瘤医学》2016年第8期1246-1248,共3页Journal of Modern Oncology

基　　金：吴阶平医学基金会资助项目(编号:320.6750.12174)

摘　　要：目的:评价CIK细胞免疫治疗晚期消化道肿瘤的临床疗效。方法:选择2010年1月至2014年12月武汉市第五医院肿瘤中心晚期消化系统恶性肿瘤患者。观察组接受CIK细胞免疫治疗,对照组给予姑息减症治疗。比较两组患者总体生存率、无疾病进展生存率,淋巴细胞亚群情况。结果:观察组64例,对照组147例。两组病例年龄、性别、分期、肿瘤部位分布构成无统计学差异。淋巴细胞亚群比较,仅CD3^+两组有统计学差异(P=0.042),观察组和对照组中位无疾病进展生存时间分别为(5±0.8)月、(4±0.4)月,总体中位生存时间分别为(25±7)月、(30±3)月,两组比较,均无统计学差异,P值分别为0.066和0.240。结论:晚期消化系统恶性肿瘤患者,CIK细胞免疫治疗对于改善肿瘤负荷小、生物学特性稍好的晚期消化系统恶性肿瘤的无疾病进展生存可能有一定意义,但总体生存无明显获益。Objective： To evaluate the clinical efficacy of CIK cells in the treatment of advanced gastrointestinal cancer. Methods： Patients with advanced digestive system carcinoma of Wuhan Fifth Hospital from January 2010 to December were selected. Patients of oberservation group were treated with CIK cells,patients of control group were treated only by palliative care. The overall survival rate and diseases progress free survival rate of the two groups were compared. Results： Sixty four patients were in observation group and 147 cases in control group. There was no significant difference in age,gender,stage and tumor location in two groups. Only CD3＋of lymphocyte subsets of two groups had significant difference（ P = 0. 042）,disease progression free survival time of observation group and control group was（ 5 ± 0. 8） months,（ 4 ± 0. 4） months,respectively,and overall survival time of two groups was（ 25 ± 7） months and（ 30 ± 3） months,respectively,no significant difference was observed in the two groups and P value were 0. 066 and 0. 240,respectively. Conclusion： For patients with advanced digestive system malignant tumor,CIK cell immunotherapy might have positive significance about disease progression free survival in those whose tumor-burden was small and had preferable biological behavior but overall survival benefit was not found.

关 键 词：细胞因子诱导杀伤细胞 生物治疗 消化系统肿瘤 

分 类 号：R735[医药卫生—肿瘤] R730.5[医药卫生—临床医学]