自噬及自噬基因Beclin1在消化道肿瘤中的研究进展  

Progression in the study of autophagy and autophagy related gene Beclin1 in human gastrointestinal neoplasms

作　　者：姚艺阳 师水生[2] 

机构地区：[1]山西医科大学,太原030001 [2]山西医科大学第二临床医学院消化内科,太原030001

出　　处：《中华临床医师杂志（电子版）》2016年第3期414-417,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：自噬是一个将细胞质中"废物"进行包装,与溶酶体结合的分解代谢过程。自噬的分解代谢是一个循环再利用的过程,它将有毒物质在细胞中清除,剩余有用物质如氨基酸则回收再供细胞利用,从而保持细胞内环境的动态平衡。自噬活性的改变与消化道肿瘤的增殖及迁移有着密切关联,自噬相关基因特别是Beclin1在其中起关键调控作用。了解自噬过程及自噬相关基因Beclin1在消化道肿瘤中的研究现状,希望肿瘤以及自噬相关疾病在未来可以得到解决。Autophagy is a catabolic process that packs the waste of cytoplasm and combines with lysosome. The catabolism of autophagy is a recycling process, which removes the toxic substances from cells and recycles the remaining useful substances such as amino acid for cell＇s use so as to maintain the dynamic balance in intracellular environment. The changes in autophagy activity are closely associated with the gastrointestinal neoplasms proliferation and metastasis. Autophagy-related genes, particularly Beclin1, play a key regulatory role in the activity. Current research situation of autophagy process and autophagy-related gene Beclin1 in gastrointestinal neoplasms is ascertained in the hope of finding a solution to tumors and autophagy-related diseases.

关 键 词：胃肠肿瘤 自噬 基因 

分 类 号：R735[医药卫生—肿瘤]