二硫代氨基甲酸酯类三唑衍生物的合成及抗真菌活性研究  

Synthesis and antifungal activities of novel triazole derivatives with dithiocarbamates side chain

作　　者：柯学峰 张治强[1] 吴茂诚[1] 柴晓云[1] 吴秋业[1] 潘炜华[2] 

机构地区：[1]第二军医大学药学院有机化学教研室,上海200433 [2]第二军医大学长征医院皮肤科,上海200003

出　　处：《药学服务与研究》2016年第1期11-14,共4页Pharmaceutical Care and Research

基　　金：上海市科学技术委员会重点攻关课题(09DZ1976700;10DZ2220100)

摘　　要：目的:合成新型二硫代氨基甲酸酯类三唑衍生物,并研究其抗真菌活性。方法:设计合成新化合物,其结构通过1 H-NMR和13 C-NMR确证,并测试其体外抑菌活性。结果:10个新化合物均为首次报道,且具有一定的抗真菌活性,部分化合物的体外抗真菌活性测试结果优于对照药。讨论:侧链中二硫代氨基甲酸酯的引入可提高化合物体外抗真菌活性。Objective：To synthesize a series of novel triazole derivatives with dithiocarbamates side chain and evaluate their antifungal activities.Methods：The novel compounds were synthesized and their chemical structures were identified by1 H-NMR and 13 C-NMR.The in vitro antifungal activities of the synthesized compounds were evaluated.Results：Ten synthesized compounds,which were reported for the first time,had certain antifungal activity,and the in vitro antifungal activity of some compounds was superior to that of the control drugs.Conclusion：The introduction of dithiocarbamates side chain could improve the antifungal activity of the compounds.

关 键 词：三唑类衍生物 化学合成 抗真菌活性 

分 类 号：R914.5[医药卫生—药物化学] R962[医药卫生—药学]