肠道菌群失调与肝细胞癌  

Intestinal dysbacteriosis in patients with hapatocellular carcinoma

作　　者：梁素妨 许琳[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院消化内科,山东省青岛市266000

出　　处：《实用肝脏病杂志》2016年第2期245-248,共4页Journal of Practical Hepatology

基　　金：青岛市公共领域科技支撑计划项目(编号:13-1-3-14-nsh);青岛市医疗卫生优秀人才培养项目资助

摘　　要：大量研究表明,肝病,特别是肝硬化和肝癌患者,发生肠道菌群紊乱或细菌过度生长的机率增高,并且肠道菌群失调与肝细胞癌的发生、发展有着密切的联系;肠道菌群所产生的脂多糖(LPS)可与其识别受体Toll样受体4(TLR4)结合,通过细胞内信号转导通路介导一系列免疫炎症反应,进一步加重肝损伤,促进炎症相关的肝细胞癌发生;抗生素可通过调节肠道菌群,减少内毒素的产生等作用有可能减缓肝细胞癌的发生和发展。A tons of studies have shown that the incidence of intestinal disorder or excessive growth of flora is very high in patients with liver diseases,especially with severe liver diseases,such as liver cirrhosis,liver cancer,and there is a close relationship between the intestinal dysbacteriosis and the occurrence of hapatocellular carcinoma. Lipopolysaccharide（LPS）produced by the intestinal flora can bond its recognition receptor-Toll-like receptor 4（TLR4）,through cell internal signaling pathways,mediating a series of immune inflammatory response,leading to furtherliver damages,and promoting inflammation related to the occurrence of hepatocellular carcinoma（HCC）. Antibotics maybe retard the occurrence and development of HCC by regulating intestinal flora or reducing the endotoxin production.

关 键 词：肝细胞癌 肠道菌群 小肠细菌过度生长 脂多糖 TOLL样受体4 

分 类 号：R735.7[医药卫生—肿瘤]