基于季戊四胺席夫碱的Ni(Ⅱ)和Cu(Ⅱ)配合物的合成、结构及其抑菌活性  

Syntheses, Crystal Structures and Bacteriostatic Activities of Ni(Ⅱ) and Cu(Ⅱ) Complexes Based on Pentaerythrityltetramine Schiff Base

作　　者：张奇龙[1] 王焕宇[1] 江峰[1] 冯广卫[1] 徐红[1] 黄亚励[1] 

机构地区：[1]贵州医科大学化学教研室,贵阳550025

出　　处：《无机化学学报》2016年第3期464-468,共5页Chinese Journal of Inorganic Chemistry

基　　金：贵州省科技计划课题(黔科合LH字[2014]7090);贵州省教育厅自然科学研究项目(黔教合KY字[2015]415号)资助

摘　　要：以4-甲氧基水杨醛和季戊四胺进行缩合反应得到席夫碱化合物H_4L,然后将配体H_4L分别与Ni(Cl O_4)_2·6H_2O、Cu(Cl O_4)_2在乙醇溶液中进行配位反应,得到2个席夫碱配合物[Ni_2(L)]·DMF(1)和[Cu_4(L)_2(DMSO)_3]·2DMSO(2)。并用元素分析、FT-IR和X射线单晶衍射进行了表征。配合物1和2都属于三斜晶系,P1空间群,配合物1和2都为双核配合物。初步研究了配体和配合物的体外抑菌活性,结果表明,配体及其配合物1和2对金黄色葡萄球菌具有一定的抑菌活性。The Schiff base compound H4 L was synthesized from condensation reaction of 4-Methoxysalicylaldehyde with Pentaerythrityltetramine. H4 L was reacted with Ni（Cl O4）2·6H2O or Cu（Cl O4）2·6H2O to give two complexes[Ni2（L）]·DMF（1） and [Cu4（L）2（DMSO）3]·2DMSO（2）. The complexes were characterized by elemental analysis, FTIR and single crystal X-ray diffraction. The crystals of 1 and 2 belong to the triclinic system, space group P1.The complexes 1 and 2 are all binuclear complexes. The In vitro bacteriostatic activities of the ligand and complexes were tested against several kinds of bacteria. The results show that the ligand and complexes possess different bacteriostatic activities to S. aureus. CCDC： 1436577, H4L; 1436578, 1; 1436576, 2.

关 键 词：席夫碱 Ni(Ⅱ)配合物 Cu(Ⅱ)配合物 晶体结构 抑菌活性 

分 类 号：O614.813[理学—无机化学] O614.121[理学—化学]