阿司匹林在不同年龄段脑梗死患者中二级预防的效果  

Clinical study of secondary prevention of aspirin in different ages of patients with cerebral infarction

作　　者：吴学永[1] 卢常盛[1] 李上华[1] 黄雄[1] 李春梅[1] 

机构地区：[1]高州市人民医院神经内科,广东高州525200

出　　处：《临床荟萃》2016年第2期201-203,共3页Clinical Focus

摘　　要：目的探讨阿司匹林在不同年龄段脑梗死患者中二级预防的效果。方法将脑梗死患者分为暴露组（服用阿司匹林）与非暴露组（不服用阿司匹林或任何抗血小板药物）,回顾性分析不同年龄段（41-50岁,51-60岁,61-70岁,71-80岁,81-90岁）脑梗死的复发、脑出血、蛛网膜下腔出血及消化道出血的发生率情况。结果与非暴露组比较,各个的年龄段暴露组（长期服用阿司匹林）脑梗死复发率明显降低;上消化道出血率明显增高（P〈0.05）。在61-90年龄段,暴露组脑出血和蛛网膜下腔出血增加趋势低于非暴露组（P〈0.05）。41-80岁年龄段,各暴露组脑出血率与蛛网膜下腔出血率比较无统计学意义（P〉0.05）,而在71-90岁之间,各暴露组脑出血率与蛛网膜下腔出血率增加（P〈0.05）。需治疗例数在71-90岁年龄段增加（P〈0.05）;在61-70岁年龄段相对危险度最高,81-90岁年龄段归因危险度最大。结论阿司匹林在不同年龄段脑梗死患者中二级预防效果存在差异,41-60岁之间应用阿司匹林进行二级预防获益最大,风险最小。Objective To explore the secondary preventive effect of aspirin in different ages of patients with cerebral infarction.Methods A retrospective analysis was applied in all patients with cerebral infarction who were divided into five different age groups and every age group had the exposure group（aspirin treatment）and no-exposure group（control group）.Recurrence of cerebral infarction,hemorrhage,subarachnoid hemorrhage and gastrointestinal bleeding were compared among groups.Results Incidence of recurrence of cerebral infarction in exposure groups were significantly lower than that of no-exposure groups（P〈 0.05）and no-exposure groups had significantly lower incidence of gastrointestinal bleeding（P〈 0.05）among different age groups.The increased incidence of cerebral and subarachnoid hemorrhage in exposure groups significantly decreased（P〈 0.05）compared with no-exposure groups at61-90 ages.In exposure groups at 41-80 ages,there were no significant difference in incidence of cerebral and subarachnoid hemorrhage（P〉 0.05）.However,the incidence of cerebral and subarachnoid hemorrhage raised significantly at 71-90ages（P〈 0.05）.The number of patients who needed treat ment increased significantly at 71-90ages（P〈 0.05）;The relative risk was highest at 61-70 ages and the attributive risk was highest at 81-90 ages.Conclusion There were differences in secondary prevention of aspirin in different ages of patients with cerebral infarction.There were maximum benefit and minimum risk to have secondary prevention of aspirin in patients with cerebral infarction at 41-60 ages.

关 键 词：脑梗死 阿司匹林 二级预防 

分 类 号：R743.33[医药卫生—神经病学与精神病学]