井穴放血疗法对卒中后抑郁患者抑郁状况和血清5-羟色胺水平的影响研究  

Influence of Jing-well Point Blood-letting Therapy on the Depression Status of Patients With Post-stroke Depression and Serum 5-HT Level

作　　者：杨丹[1] 巫升冰 曾贤[1] 杨梅[3] 杨孝芳[4] 

机构地区：[1]贵阳中医学院第二附属医院康复科,贵州省贵阳市550003 [2]洪雅县中医医院康复科 [3]贵阳中医学院第二附属医院检验科 [4]贵阳中医学院针推系

出　　处：《中国全科医学》2016年第4期486-488,共3页Chinese General Practice

基　　金：贵州省科技厅资助课题(黔科合J字[2012]LKZ7016号)

摘　　要：目的探讨井穴放血疗法对卒中后抑郁(PSD)患者抑郁状况和血清5-羟色胺(5-HT)水平的影响。方法选取于2012年6月—2013年12月在贵阳中医学院第二附属医院康复科进行治疗的PSD患者80例,随机分为对照组和观察组各40例。两组患者均进行常规内科治疗和肢体康复治疗,对照组在常规治疗基础上口服帕罗西汀,观察组在常规治疗基础上加用井穴放血疗法,均治疗2个疗程。比较两组治疗前后的汉密尔顿抑郁量表(HAMD)评分和血清5-HT水平。结果两组性别、平均年龄、平均病程及卒中类型分布比较,差异无统计学意义(P>0.05)。治疗前两组血清5-HT水平比较,差异无统计学意义(P>0.05);治疗后两组HAMD评分比较,差异亦无统计学意义(P>0.05);治疗后两组HAMD评分与治疗前比较,差异有统计学意义(P<0.05)。治疗前两组血清5-HT水平比较,差异无统计学意义(P>0.05);治疗后两组血清5-HT水平比较,差异亦无统计学意义(P>0.05);治疗后两组血清5-HT水平与治疗前比较,差异有统计学意义(P<0.05)。结论井穴放血疗法可以改善PSD患者的抑郁状况,其机制可能与降低血清5-HT水平有关。Objective To investigate the influence of Jing-well point blood-letting therapy on the depression status of patients with post-stroke depression（ PSD） and serum 5-HT level. Methods We enrolled 80 PSD patients who were treated in the Department of Rehabilitation of the Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine from June2012 to December 2013. The subjects were randomly divided into control group（ n = 40） and observation group（ n = 40）. The two groups were administrated with conventional medical treatment and limb rehabilitation therapy,on the basis of which the control group was also orally administrated with paroxetine and the observation group was also administrated with Jing-well point blood-letting therapy. And both group underwent two courses of treatment. Comparison was made between the two groups in HAMD score and serum 5-HT level. Results The two groups were not significantly different in gender,average age,average length of disease and type distribution of stroke（ P 〉0. 05）. Before treatment,the two groups were not significantly different in HAMD score（ P 〉0. 05）; after treatment,the two groups were not significantly different in HAMD score（ P 〉0. 05）; after treatment,HAMD scores of the two groups were significantly different from those before treatment（ P 〈0. 05）. Before treatment,the two groups were not significantly different in serum 5-HT level（ P 〉0. 05）; after treatment,the two groups were not significantly different in serum 5-HT level（ P 〉0. 05）; after treatment,the two groups were significantly different from those before treatment（ P 〈0. 05）. Conclusion Jing-well point blood-letting therapy can alleviate the depression status of PSD patients,and the mechanism may be related with the reduction of serum 5-HT level.

关 键 词：卒中后抑郁 放血疗法 穴 井(五输) 血清素 

分 类 号：R749.41[医药卫生—神经病学与精神病学]