AIH患者外周血PD-1表达与肝脏炎症活动度的相关性分析  

Expression of PD-1 on Peripheral Blood T Cells and the Correlation With Liver Inflammatory Activity in Patients With Autoimmune Hepatitis

作　　者：熊克宫[1] 陈丽芳[1] 柯坤宇[1] 

机构地区：[1]福州市传染病医院肝病科,350012

出　　处：《中国卫生标准管理》2016年第2期34-36,共3页China Health Standard Management

基　　金：福州市卫生系统科技计划项目(2014-S-w21)

摘　　要：目的研究细胞表面程序性死亡受体1(PD-1)与肝脏病变程度的相关性。方法收集43例AIH患者,并选择18例健康体检者为对照组。采用流式细胞术检测外周血CD4^+、CD8^+T细胞中PD-1的表达。结果 AIH组外周血CD4^+、CD8^+T细胞表达PD-1的细胞百分比高于对照组(P<0.05);AIH活动期组外周血CD4^+、CD8^+T细胞表达PD-1的细胞百分比高于缓解期组和对照组(P<0.05)。外周血CD4^+、CD8^+T细胞PD-1的表达在AIH患者病理重度炎症组、轻度炎症组及缓解期逐渐下降(P<0.05)。结论 PD-1可作为评判肝脏炎症活动度的参考指标之一。Objective To investigate the correlation of programmed cell death receptor 1（PD-1）with liver inflammatory activity. Methods The percentages of PD-1 on CD4-＋,CD8-＋T lymphocytes in peripheral blood of patients with AIH（n=43）and healthy controls（n=18）was determined by flow cytometry. Results We found that the percentages of PD-1 on CD4-＋,CD8-＋T lymphocytes in peripheral blood of patients with AIH were higher than the healthy controls. The percentages of PD-1 on CD4-＋,CD8-＋T lymphocytes peripheral blood in activity stage,remission stage and the control group were gradually declined. The expression of PD-1 in severe inflammation,mild inflammation and remission stage were gradually decline,and PD-1 expression was a positively correlated with inflammation grading of hepatitis tissues. Conclusion PD-1 can be used as a reference index evaluation of liver inflammatory activity.

关 键 词：自身免疫性肝炎 PD-1 T细胞 肝脏炎症活动度 

分 类 号：R575.1[医药卫生—消化系统]