双相Ⅰ型障碍抑郁发作患者血清尿酸水平及其影响因素  

Study on the level and relative factors of serum uric acid in the patients with depressive episodes of bipolar Ⅰ disorder

作　　者：陈红梅[1] 陈景旭[1] 梁雪梅 刘可智 王璇[1] 张立刚[1] 王绍礼[1] 

机构地区：[1]北京大学回龙观临床医学院,北京100096 [2]西南医科大学附属医院,四川泸州646000

出　　处：《四川精神卫生》2016年第1期10-13,共4页Sichuan Mental Health

基　　金：首都临床特色应用研究(Z131107002213099)

摘　　要：目的调查双相I型障碍抑郁发作患者血清尿酸(UA)水平及其影响因素。方法采用横断面研究,选取双相I型障碍抑郁发作患者(患者组)68例和健康人群(对照组)68例。采用全自动生化仪检测血清UA水平,采用汉密尔顿抑郁量表(HAMD)评定患者抑郁严重程度。结果患者组高尿酸血症(HUA)检出率高于对照组,差异有统计学意义(20.6%vs.7.4%,P<0.05);患者组血清UA水平与对照组比较差异有统计学意义[(310.31±83.35)μmol/L vs.(282.47±78.30)μmol/L,P<0.05],患者组男性UA水平高于女性[(344.40±100.45)μmol/L vs.(296.10±71.59)μmol/L,P<0.05]。相关分析显示:UA水平与性别和精神病家族史呈负相关(r=-0.28、-0.27,P均<0.05);与甘油三酯水平呈正相关(r=0.34,P<0.01)。逐步多元回归分析显示,性别、阳性精神疾病家族史对血清UA水平有明显影响(P均<0.01)。结论双相I型障碍抑郁发作患者UA水平增高,并与性别、精神疾病家族史相关。Objective To explore the serum levels of uric acid( UA) and relative factors in the patients with depressive episodes of bipolar I disorder. Methods The case-control study was used for the investing. A total of 68 inpatients with depressive episodes of bipolar disorder( patient group) and 68 healthy individuals( control group) were enrolled. Serum levels of UA was measured by automatic biochemical analyzer. Hamilton Depression Scale( HAMD) was used to evaluate the severity of depression.Results The prevalence rate of hyperuricemia( HUA) was 20. 6% in the patient group and 7. 4% in the control group( P < 0. 05).There was a statistical difference in serum UA levels between the patient group and the control group [( 310. 31 ± 83. 35) μmol / L vs.( 282. 47 ± 78. 30) μmol/L,P <0. 05],and serum UA levels was higher in men than in women in the patient group[( 344. 40 ±100. 45)μmol /L vs.( 296. 10 ± 71. 59) μmol /L,P < 0. 05]. Correlation analysis showed gender and positive family history of mental illness had negatively correlation( r =-0. 28,-0. 27,P < 0. 05) and triglyceride had positive correlation( r = 0. 34,P < 0. 01) with serum levels of UA. Stepwise multiple regression analysis showed gender and positive family history of mental illness were associated with serum levels of UA among the patients( P < 0. 01). Conclusion The serum UA levels in the patients with depressive episodes of bipolar I disorder increases,which is associated with gender,positive family history of mental illness.

关 键 词：双相障碍 抑郁发作 尿酸 高尿酸血症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]