miRNA靶向mTOR相关信号通路对肿瘤的影响  

Effect of mi RNAs targeted m TOR signal pathway on tumor

作　　者：黄楠[1] 张思[1] 潘霞[1] 臧婧蕾 王智慧[1] 李茜[1] 雷小勇[1] 

机构地区：[1]南华大学药物药理研究所,湖南省分子靶标新药研究协同创新中心,衡阳421000

出　　处：《生命的化学》2016年第1期88-96,共9页Chemistry of Life

基　　金：国家自然科学基金项目(81372579)

摘　　要：miRNA是一类含有22个nt左右的内源性短小非编码RNA,可作用于mRNA使之降解或者抑制翻译来调节靶基因的表达。哺乳动物雷帕霉素靶蛋白(mammals target of rapamycin,mTOR)是一种丝/苏氨酸蛋白激酶,近年来有研究表明mTOR集成了多个信号通路控制着有机体的生长和体内平衡。目前,大量研究表明miRNA能靶向mTOR相关信号通路对肿瘤产生影响。因此,本文主要探讨m TOR相关信号通路与肿瘤的关系,综述miRNA靶向m TOR相关信号通路对肿瘤的影响,旨在为肿瘤的靶向性治疗提供更好的理论依据。MiRNA is a kind of endogenous non-coding RNAs of about 22 nt in length. Mi RNA regulates the expression of target genes through degradation or translation inhibition of target m RNA. Mammalian target of rapamycin（mTOR） is a type of serine/threonine protein kinase. Recent studies have showed that mTOR is closely related to multiple signaling pathways concerning growth and homeostasis. Mi RNA is widely accepted to have effects on tumors by targeting mTOR related signaling pathways. Here, to provide a better theoretical basis for the targeting therepy of tumors, the paper mainly concerns the relationships of mTOR related signaling pathways with tumors.

关 键 词：MIRNA mTOR相关信号通路 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]