肺癌侵袭和转移分子机制研究进展  

Research Advances in Molecular Mechanisms of the Invasion and Metastasis of Lung Cancer

作　　者：刘贤忠[1] 张丽婷[1] 童卫泉 王帅[1] 徐志波[1] 陈芳[2] 

机构地区：[1]浙江中医药大学第一临床医学院呼吸科,杭州310053 [2]浙江中医药大学第一附属医院肺功能室,杭州310006

出　　处：《中国医学科学院学报》2016年第1期108-112,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81302934);浙江省科技厅钱江人才计划(2012R10063)~~

摘　　要：肺癌侵袭和转移的基本方式是细胞外基质中肿瘤细胞的脱落,周围组织和基底膜的侵袭,渗入血流,通过血流生存和运输,在远处位点外渗、迁移和逮捕,最后形成转移性病灶。这些步骤需要基本的机制,如肿瘤干细胞、肿瘤细胞的扩散和活力、凋亡逃避、血管生成和淋巴管生成、渗入和循环及渗出血流、远处转移的增殖等,这些都与肺癌侵袭和转移有关。更好地理解肺癌侵袭和转移的机制,能更有效地预防和治疗肺癌。The basic way of invasion and metastasis of lung cancer is that the tumor cells shed in the extracellular matrix,invade the basement membrane and the surrounding tissue, infiltrate into blood flow, and then survive and transport via the blood flow. After having been extravasated,migrated and arrested in the distant site,they finally form a metastatic lesion. Some basic mechanisms are required in these steps,such as tumor stem cells,diffusion and activity of tumor cells,escaping from apoptosis,angiogenesis and lymphangiogenesis,infiltration into blood flow,circulation and exudation,and distant metastasis proliferation. A better understanding of the mechanisms of the invasion and metastasis of lung cancer will facilitate the prevention and treatment of lung cancer.

关 键 词：肺肿瘤 侵袭 转移 分子机制 

分 类 号：R734.2[医药卫生—肿瘤]