开胸手术对非小细胞肺癌患者血清VEGF、MMP-9水平变化的影响分析  

Effect of Thoracotomy on Serum VEGF and MMP-9 Levels in Non-small Cell Lung Cancer

作　　者：梁葳[1] 章海波[1] 黄壮荣[1] 祝曙光[1] 陈凯[1] 

机构地区：[1]广东药学院附属第一医院,510080

出　　处：《实用癌症杂志》2016年第3期369-372,共4页The Practical Journal of Cancer

基　　金：广东省科技计划项目(编号:20130319c)

摘　　要：目的分析开胸手术对非小细胞肺癌(non-small cell lung cancer)患者血清VEGF、MMP-9水平变化的影响。方法将非小细胞肺癌患者79例作为观察组;良性肺部疾病患者56例和健康志愿者25例作为对照组。观察组患者和良性肺部疾病患者均进行了开胸肺切除手术,然后按照病理类型和TNM分期对观察组患者治疗前的VEGF、MMP-9水平进行检测统计,并与健康对照组比较分析,并对治疗前后观察组和良性对照组患者的VEGF、MMP-9水平进行统计分析。结果按照患者病理类型检测VEGF水平为:腺癌(332.3±82.3)pg/ml,鳞癌(364.5±81.8)pg/ml,其他病理类型(375.8±88.6)pg/ml;所有患者的MMP-9水平分别为腺癌(199.4±82.2)ng/ml,鳞癌(183.2±102.6)ng/ml,其他病理类型(185.1±112.9)ng/ml,所有肺癌患者的VEGF水平和MMP-9水平均显著高于健康对照组(P<0.05)。Ⅰ期患者的VEGF水平和MMP-9水平分别为(245.4±54.3)pg/ml和(141.2±58.2)ng/ml,明显低于其他分期患者VEGF水平和MMP-9水平(P<0.05)。观察组患者治疗前后VEGF水平和MMP-9水平均显著高于良性对照组患者(P<0.05)。结论开胸手术治疗非小细胞肺癌患者,术后患者的VEGF水平和MMP-9水平明显升高,但没有明显的相关性。患者术前VEGF水平和MMP-9水平也明显高于良性肺部疾病患者,且与患者的分化程度相关。Objective To analyze the effect of thoracotomy on serum VEGF and MMP-9 levels in non-small cell lung cancer. Methods 79 cases of non-small cell lung cancer were the observation group;56 cases of patients with benign lung dis- ease and 25 cases healthy volunteers were the control group. The observation group and patients with benign lung disease received open the chest lung resection, and then according to the histological type and TNM staging, VEGF and MMP-9 levels were observed in the observation group before treatment, and compared with the healthy control group. VEGF and MMP-9 levels in the observation group and the healthy control group received statistical analysis. Results According to the pathological type, VEGF level in patients with adenocarcinoma was （332.3 ±82.3 ）pg/ml, squamous （364.5 ±81.8 ）pg/ml, other pathological types （375.8 ±88.6 ） pg/ml ; MMP-9 level in patients with adenocarcinoma was （ 199.4 ± 82.2 ） ng/ml, sqnamous （ 183.2 ±102.6 ） ng/ml, other pathological types（ 185.1 ± 112.9 ） ng/ml, VEGF and MMP-9 levels of all lung cancer patients were significantly higher than those of the healthy control group （ P 〈 0.05 ）. VEGF and MMP-9 levels in stage I patients were （ 245.4 ±54.3 ） pg/ml and （ 141.2 ±58.2 ） ng/ml, which were significantly lower than patients in other staging （ P 〈 0.05 ）. VEGF levels were observed in patients before and after treatment, VEGF and MMP-9 levels were significantly higher in patients of the benign group （ P 〈 0.05 ）. Condusion After thoracotomy for non-small cell lung cancer, VEGF and MMP-9 levels significantly increased, but there has no significant correlation. Preoperative VEGF and MMP-9 levels are also significantly higher than patients with benign lung diseases, and are correlated with the degree of differentiation of patients.

关 键 词：开胸手术 非小细胞肺癌 血清MMP-9 血清VEGF 影响 

分 类 号：R734.2[医药卫生—肿瘤]