NESG1在非小细胞肺癌中的表达及临床意义  

Expression and clinical significance of nasopharyngeal epithelium cell specific protein 1( NESG1) in non-small cell lung cancer

作　　者：吴雪花[1] 王昌锋[2] 黄虎翔[2] 

机构地区：[1]黄冈市中心医院重症医学科,湖北黄冈438000 [2]黄冈市中心医院呼吸内科,湖北黄冈438000

出　　处：《临床肺科杂志》2016年第4期613-615,共3页Journal of Clinical Pulmonary Medicine

基　　金：黄冈市科技研究与开发计划项目":黄科字【2012】62号

摘　　要：目的探讨鼻咽上皮细胞特异性蛋白1（NESG1）在非小细胞肺癌（NSCLC）组织中的表达及临床意义。方法采用免疫组化Envision两步法检测64例NSCLC组织中NESG1的表达，以39例癌旁正常组织作为对照，分析NESG1在NSCLC中的表达及与患者临床病理特征的关系。结果NESGI在NSCLC中的阳性表达率26．6％（17／64），在癌旁正常组织的阳性表达率为53．8％（21／39），NSCLC中阳性表达下降，差异有统计学意义（x2=7．748，P=0．005），NESG1的表达与患者年龄、淋巴结转移、分化程度、TNM分期有关（P〈0．05），而与性别、组织学分型、肿瘤大小无关（P〉0．05）。结论NESG1基因在NSCLC中表达下调，其表达水平与多种临床特征有关，可能作为一个重要因素参与了NSCLC的发生、发展。Objective To explore the expression and clinical significance of nasopharyngeal epithelium cell specific protein 1 （ NESG1 ） in non-small cell lung cancer （NSCLC）. Methods The expression of NESG1 was detected by immunohistochemical Envision two-step method in 64 cases of NSCLC tissues, and 39 cases of normal tissue adjacent to carcinoma as comparison. The relationship between NESG1 expression and clinical pathological character- istics was analyzed. Results The positive expression rate of NESG1 in NSCLC was 26. 6% （17/64） and 53.8% （21/39） in normal tissue adjacent to carcinoma The positive expression rate declined in NSCLC tissue compared with normal tissue adjacent to carcinoma （ X2 = 7. 748, P = 0. 005 ）. The expression of NESG1 related with patients＇ age, lymph node metastasis, tumor differentiation, and TNM staging （P 〈 0. 05 ）, and nothing related with patients＇ gender, pathological type, or tumor size （P 〉 0. 05）. Conclusion The expression level of NESGI genes in NSCLC is down-regulated and associated with a variety of clinical features, which may be an important factor involve in the occurrence and development of NSCLC.

关 键 词：非小细胞肺癌 NESG1 CCDC19 表达 

分 类 号：R734.2[医药卫生—肿瘤]