血管内介入联合尤瑞克林对急性脑梗死患者神经功能与血清NSE水平的影响  

Effect of Nerve Function and Serum NSE Level of Intravascular Interventional Therapy Combined with Urinary Kallikrein on Acute Cerebral Infarction

作　　者：李朱勤[1] 刘武[1] 邓宇平[1] 罗伟良[1] 

机构地区：[1]广东省惠州市中心人民医院,广东惠州516001

出　　处：《中国医学创新》2016年第8期49-52,共4页Medical Innovation of China

基　　金：惠州市科技计划项目(2015Y006)

摘　　要：目的:探讨血管内介入联合尤瑞克林对急性脑梗死患者神经功能与血清NSE水平的影响。方法:选取2014年8月-2015年8月本院急性脑梗死患者50例,采用随机数字表法将患者分为观察组与对照组,全部患者均采用血管内介入治疗,对照组患者采用常规治疗方案,观察组患者在对照组患者的基础上采用尤瑞克林治疗。采用酶联免疫吸附试验(ELISA)测定血清神经元特异性烯醇化酶(NSE)水平,比较两组患者临床疗效神经功能与血清NSE水平的差异。结果:观察组患者治疗总有效率明显高于对照组,两组患者比较差异有统计学意义(P<0.05)。治疗后第7、14天,两组患者NIHSS评分与血清NSE水平均明显低于治疗前,治疗前后比较差异均有统计学意义(P<0.05)。治疗后第7、14天,观察组患者上述指标明显低于对照组,两组患者比较差异有统计学意义(P<0.05)。结论:血管内介入联合尤瑞克林有助于显著改善急性脑梗死患者神经功能与血清NSE水平,从而改善疾病预后状况,值得临床推广应用。Objective： To evaluate the effect of nerve function and serum NSE level of intravascular interventional therapy combined with Urinary Kallikrein on acute cerebral infarction. Method： 50 patients with acute cerebral infarction were selected in our hospital during August 2014 to August 2015, using the random number table method, the patients were divided into observation group and control group. All patients were treated by endovascular interventional therapy, the control group was treated with conventional therapy, the observation group was given Urinary Kallikrein in the based on control group. Serum neuron specific enolase （ NSE ） were detected by enzyme-linked immunosorbent assay （ ELISA ）, and the differences of clinical efficacy, neurological function and serum NSE level between the two groups were compared. Result： The total effective rate in the observation group was significantly higher than that control group, the difference was statistically significant between the two groups （ P〈0.05 ） . After treatment with 7 d and 14 d, all patients NIHSS score and serum NSE levels were significantly lower than pre-therapy, the differences were statistically significant（ P〈0.05 ） . After treatment with 7 d and 14 d, the above indexes between the observation group were significantly lower than control group, the differences were statistically significant between the two groups （ P〈0.05 ） . Conclusion： Intravascular intervention combined with Urinary Kallikrein helps to significantly improve neurologic function and serum NSE level for acute cerebral infarction, so as to improve the disease prognosis, it is worth of clinical application.

关 键 词：血管内介入 尤瑞克林 急性脑梗死 神经功能 NSE 

分 类 号：R743.3[医药卫生—神经病学与精神病学]