醛固酮合成酶基因多态性与原发性高血压靶器官损伤的关系研究  

Study of association of CYP11B2 gene- 344C / T polymorphism with target organ damage in primary hypertension patients

作　　者：张红艳[1] 张志涛[2] 

机构地区：[1]河北工程大学医学院,河北邯郸056002 [2]邯郸市中心医院泌尿外二科,河北邯郸056002

出　　处：《现代预防医学》2016年第5期880-882,909,共4页Modern Preventive Medicine

基　　金：河北省科技厅基金支持;项目名称:邯郸地区汉族人群高血压相关基因多态性与原发性高血压靶器官损伤的关系研究(项目编号:11276103D-51)

摘　　要：目的探讨CYP11B2基因-344C/T多态性与原发性高血压及其靶器官损伤的关系。方法检测对照组、原发性高血压无并发症组、高血压合并脑梗死组和高血压左室肥厚组患者的CYP11B2基因型频率,统计学分析比较其差异。结果高血压组和对照组的C等位基因频率分别为0.28、0.19,统计学分析提示高血压组的C等位基因频率显著高于对照组(P<0.01);高血压合并脑梗死组与无并发症组的C等位基因频率分别为0.33、0.27,两者之间无显著差别(P>0.05);高血压合并脑梗死组与无并发症组的T等位基因频率分别为0.67、0.73,两者之间无显著差别(P>0.05);高血压左室肥厚组和无并发症组的T等位基因频率分别为0.78、0.73,高血压左室肥厚组显著高于无并发症组(P<0.005)。结论 CYP11B2基因C等位基因可能是原发性高血压的一个遗传标志。高血压合并脑梗死的发生与CYP11B2基因多态性无关,高血压左室肥厚的发生与CYP11B2基因T等位基因有关。Objective To study the association of CYP11B2 gene -344C/T polymorphism with target organ damage in primary hypertension patients. Methods CYPllB2 genotypes were detected in the control group, primary hypertension with no complications group, primary hypertension with left ventricular hypertrophy group and primary hypertension with cerebral infarction group,respectively. Then statistical analysis was done to compare the differences. Results The frequency of C allele in hypertension group （0.28） was higher than that in the control group （0.19） with 0. 01 〉 P 〉 0. 005. The frequency of C allele in primary hypertension with cerebral infarction group and primary hypertension with no complications group were 0.33 and 0.27 ,and there was no significant difference between the two groups （ P 〉 0.05 ）. The frequency of T allele in primary hypertension with cerebral infarction group and primary hypertension with no complications group were 0.67 and 0.73, and there was no significant difference between the two groups （P 〉 0.05）. The frequency of T allele in primary hypertension with left ventricular hypertrophy group （0.78） was higher than that of primary hypertension with no complications group （0.73） with P 〈0. 005. Conclusion CYPllB2 gene C allele is a genetic mark of primary hypertension. Primary hypertension with cerebral infarction has no correlation with CYPllB2 gene -344C/T polymorphism. Primary hypertension with left ventricular hypertrophy has a correlation with CYP11 B2 gene T allele.

关 键 词：原发性高血压 靶器官损伤 CYP11B2基因 -344C/T多态性 高血压合并脑梗死 高血压左室肥厚 

分 类 号：R181.38[医药卫生—流行病学]