脑电图技术在帕金森病临床研究中的应用  

The clinical application of EEG in Parkinson's disease

作　　者：王培培[1] 王静[1] 陈昭燃[1] 李俊发[1] 

机构地区：[1]首都医科大学神经生物学系北京脑重大疾病研究院,北京100069

出　　处：《基础医学与临床》2016年第3期406-410,共5页Basic and Clinical Medicine

基　　金：北京市教委科研基地科技创新平台(PXM2011-014226-07-000072)

摘　　要：帕金森病(PD)是中老年期高发神经退行性疾病之一,其特点是患者出现明显症状时不可逆转的神经变性已发生,治疗与预后均不理想。脑电图(EEG)是神经科学研究的重要内容与手段,能够以高时间分辨率连续记录全脑电活动,并被广泛应用于PD研究中。本文回顾EEG在PD临床研究中的应用,从非运动症状、运动症状研究和疗效评估3方面展开。最后论述其临床应用优势,并讨论EEG的局限性及其应用展望。Parkinson＇s disease （PD） is a common neurodegenerative disease in middle-aged and elderly popula- tion. PD patients with observable symptoms suffer from irreversible degeneration of neural system, but the treatment and prognosis are challenging. Electroencephalography （EEG） is an important approach in neuroscience research, which could record electrical signals from the entire brain with high temporal resolution, and it is widely applied to clinical PD research. This review focuses on EEG investigations on non-motor symptoms, motor symptoms, and treatment efficacy of PD. The advantages and limitations of EEG technique in clinical applications are also dis- cussed.

关 键 词：帕金森病 脑电图 临床应用 优势 局限性 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]