GP73和AFP联合检测在原发性肝癌中的诊断价值  

Value of combined detection of GP73 and AFP in diagnosis of primary hepatic carcinoma

作　　者：朱波[1] 肖亚雄[1] 彭宇生[1] 王鹏[1] 张文礼[2] 樊建新[3] 

机构地区：[1]四川省宜宾市第一人民医院检验科,644000 [2]四川省宜宾市第一人民医院消化内科,644000 [3]四川省宜宾市第一人民医院普外科,644000

出　　处：《检验医学与临床》2016年第5期595-596,599,共3页Laboratory Medicine and Clinic

基　　金：四川省卫计委科研课题资助项目(110600);四川省宜宾市科技局重点科技计划项目(2011SF004)

摘　　要：目的探讨高尔基体蛋白73(GP73)和甲胎蛋白(AFP)联合检测在原发性肝癌(PHC)诊断中的价值。方法 AFP采用微粒子化学发光法,用美国雅培ARCHITECT i2000SR全自动化学发光仪进行定量检测;GP73采用ELISA法作定量检测,分别对PHC组105例,普通肝病组47例,其他肿瘤对照组43例和健康对照组50例进行两项指标的定量检测和分析。结果 PHC组血清GP73水平均明显高于普通肝病组、其他肿瘤组和健康对照组,差异有统计学意义(P<0.05);GP73、AFP及二者联合检测对诊断PHC的灵敏度分别为79.05%、62.86%、94.29%,其受试者工作特征曲线(ROC曲线)下面积(AUC)分别为:0.84、0.71、0.95。结论 GP73和AFP联合检测能提高PHC诊断的敏感性和诊断价值。Objective To investigate the value of combined detection of GP73 and AFP in the diagnosis of primary hepatic carcinoma（PHC）.Methods AFP was quantitatively detected with the microparticle chemiluminescence method by the USA Abbott ARCHITECT i2000 SR automatic chemiluminescence instrument;GP73was quantitatively detected by ELISA;these two indicators were detected in 105 cases of the PHC group,47 cases of the normal liver disease group,43 cases of the other tumors control group and 50 cases of the healthy control group and the detection results were analyzed.Results Serum GP73 level inn the PHC group was significantly higher than that in the normal liver disease group,other tumors group and healthy control group,the differences were statistically significant（P〈0.05）;the sensitivity of GP73 and AFP combined detection for diagnosis of PHC was 79.05%,62.86%and 94.29%respectively,and the area under curve（AUC）of receiver operating characteristic（ROC）curve was 0.84,0.71and0.95 respectively.Conclusion The combined detection of serum GP73 and AFP can improve the sensitivity and diagnostic value of PHC diagnosis.

关 键 词：原发性肝癌 甲胎蛋白 高尔基体蛋白73 诊断价值 

分 类 号：R735.7[医药卫生—肿瘤]