血流感染患者D-二聚体测定的临床意义  

Clinical significance of plasm D-dimer detection in patients with bloodstream infection

作　　者：王书侠[1] 张家明[1] 姚孝明[1] 陈光毅[1] 钟丽[1] 陈娟[1] 

机构地区：[1]南京中医药大学附属中西医结合医院/江苏省中医药研究院检验科,南京210028

出　　处：《检验医学与临床》2016年第5期628-629,632,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨急性血流感染（BSI）患者血浆D-二聚体的水平及临床意义。方法胶乳增强免疫比浊法检测111例BSI患者和38例非BSI患者的血浆D-二聚体水平,比较两组D-二聚体水平的差异。结果 BSI患者的D-二聚体水平[2.034（1.190～4.666）mg/L]明显高于非BSI者[0.966（0.157～2.056）mg/L],差异有统计学意义（P〈0.01）;BSI患者革兰阳性球菌感染组的D-二聚体水平[2.054（1.097～4.768）mg/L]与革兰阴性杆菌感染组[1.824（1.291～4.814）mg/L]相比,差异无统计学意义（P〉0.05）。结论 BSI患者体内存在着凝血和纤溶活性的异常,D-二聚体可作为非特异性炎性指标,辅助血流感染患者病情及疗效的监测。Objective To investigate the level and clinical significances of plasma D-dimer in the patients with the acute blood stream infection（BSI）.Methods The latex enhanced immune turbidimetric method was adopted to detect plasma D-dimer level in 111 cases BSI and 38 cases of non-BSI.The detection results were compared between BSI and non-BSI.Results The D-dimer level in the BSI patients was 2.034（1.190-4.666）mg/L,which was significantly higher than 0.966（0.157-2.056）mg/L in the non-BSI patients,the difference was statistically significant（P〈0.01）;the D-dimer level had no statistical difference between the Gram-positive cocci infection and Gram-negative bacilli infection[1.824（1.291-4.814）mg/L vs.[2.054（1.097-4.768）mg/L,P〉0.05 ].Conclusion The abnormality of coagulation and fibrinolysis activity exists in the BSI patients.D-dimer can be used as a nonspecific inflammation index for auxiliarily monitoring the disease condition and curative effect in the BSI patients.

关 键 词：D-二聚体 血流感染 临床意义 

分 类 号：R743.33[医药卫生—神经病学与精神病学]