microRNA-17过表达对胶质瘤患者预后的影响  

Influence of expression level of miR-17 on prognosis of glioma patients

作　　者：李星光 卢圣奎[2] 王帅[2] 

机构地区：[1]元氏县中医院神经外科,石家庄051130 [2]河北医科大学第二医院神经外科

出　　处：《脑与神经疾病杂志》2016年第3期168-171,共4页Journal of Brain and Nervous Diseases

摘　　要：目的探讨微小RNA-17(miR-17)在胶质瘤细胞中的表达与人脑胶质瘤患者预后的相关性。方法实时定量PCR(qRT-PCR)分析miR-17在108胶质瘤组织和20正常脑组织中的表达情况。采用Kaplan-Meier法分析miR-17过表达胶质瘤患者预后的关联性。结果与正常脑组织比较中,miR-17在胶质瘤组织中的表达显著增高(P<0.001),且miR-17在胶质瘤的表达水平随肿瘤病理分级的增高而增高(P<0.01)。Kaplan-Meier生存和Cox回归分析显示,miR-17高表达是预测胶质瘤预后不良的独立因素(P<0.01)。此外,分析还显示miR-17的高表达与胶质瘤患者整体不良预后显著相关(P<0.001)。结论本研究显示,miR-17高表达量可能对预测胶质瘤患者的不良预后具有潜在价值,表明了miR-17高表达可能有助于脑胶质瘤的进展,并成为将来生物治疗的靶点。Objective To investigate the correlation of expression of miR-17 in glioma cells and prognosis of glioma patients.Methods qRT-PCR was used to determine the expression level of miR-17 in 108 glioma samples and 20 non-neoplasma brain samples. Kaplan-Meier test was used to investigate the relationship between expression of miR-17 and prognosis of glioma patients. Rseults Comparing to control group,the expression of miR-17 was significantly increased in glioma tissues（ P 〈0. 001）,and higher expression level of miR-17 was found in glioma tissues of higher WHO grade（ P〈 0. 01）. The results of K-M analysis and Cox regression analysis showed that high expression of miR-17 was an independent factor for poor prognosis（ P〈0.01） and was significantly related to the poor prognosis of glioma patients. Conclusion This study shows that high expression of miR-17 could indicate poor prognosis of glioma patients. miR-17 may promote the development of glioma and could be a therapeutic target.

关 键 词：microRNA-17 胶质瘤 表达 预后 

分 类 号：R739.4[医药卫生—肿瘤]