肝癌肝移植术后受体预后相关因素的研究进展  

Advances on the Research of Predicting the Prognosis of Hepatocellular Carcinoma Recipients After Liver Transplantation

作　　者：王利英[1] 郑树森[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《肿瘤学杂志》2016年第2期145-151,共7页Journal of Chinese Oncology

基　　金：国家自然科学基金创新群体(81121002)

摘　　要：原发性肝癌是世界上最高发的恶性肿瘤。肝移植为肝癌的根治性治疗带来了希望,但是肝移植术后肿瘤的复发等严重地制约了受体术后的长期生存。因此,有效防治肝癌肝移植术后的肿瘤复发、延长生存时间已经成为急需解决的肝移植的重要课题,筛选有效的预测肝癌预后的影响因素、建立肝移植术后肿瘤预后预警机制,对改善肝癌肝移植受体术后的预后具有重要意义。自肝移植开展以来,肝移植学术界围绕肝移植术后肝癌受体复发和生存的防治问题,进行了大量的临床研究及基础研究,包括肝癌肝移植受者选择标准、肝移植术后肿瘤复发及预后因素等方面,并取得了诸多的研究成果。杭州标准是我国肝移植学者提出的、首个被国际移植学界广泛接受的肝癌肝移植标准,更符合我国目前的国情,在引领肝癌肝移植领域的发展中作出了重要贡献。Hepatocellular carcinoma（HCC） is one of the most prevalent malignant tumors worldwide.Liver transplantation（LT） is known as a curative and therapeutic modality. However,the survival rates of recipients after LT are still not good enough because of recurrence. To improve the survival rates of recipients after LT,to identify predictive factors for prognosis after LT and to establish a model assessing prognosis are all important to hepatocellular carcinoma recipients.Plenty of clinical and basic researches have been done on recurrence and prognosis after LT recently.Lots of progress have been made especially in LT recipients selection criteria and risk factors for predicting prognosis after LT. Hangzhou criteria,in line with China＇s current situation,is first proposed by our Chinese scholars of LT,and is accepted worldwidely,making important contributions to the development of LT.

关 键 词：肝肿瘤 肝移植 复发 危险因子 预后 

分 类 号：R735.7[医药卫生—肿瘤]