SALL4及其在非生殖细胞恶性肿瘤中的临床应用价值  

SALL4 and its clinical application value in non-germ cell tumors

作　　者：陈园园[1] 叶园园[1] 徐枫[1] 李志臻[1] 刘颖斌[1] 韩宝三[1] 

机构地区：[1]上海交通大学医学院附属新华医院普外科上海交通大学医学院胆道疾病研究所,200092

出　　处：《国际肿瘤学杂志》2016年第2期155-158,共4页Journal of International Oncology

基　　金：国家自然科学基金(81172078) National Natural Science Foundation of China

摘　　要：婆罗双树样基因4 （SALL4）在胚胎干细胞和肿瘤细胞的增殖、多能性维持方面发挥着重要作用.在完全分化的细胞中,SALL4基因的表达被沉默或者下调,而在多种非生殖细胞恶性肿瘤中SALL4基因被再次激活,表达上调,并且SALL4的表达水平常常与疾病的进程、治疗效果及预后相关.因此,SALL4的检测对于非生殖细胞恶性肿瘤的诊断以及病情监测具有重要意义.Sal-like 4 （SALL4） plays an important role in promoting the cellular proliferation and maintaining the pluripotency of embryonic stem cells and tumor cells.In fully differentiated cells,the expression of SALL4 is silenced or down-regulated.However,the expression of SALL4 is found to be restored or up-regulated in a variety of non-germ cell tumors.Besides,the expression of SALL4 is often associated with disease progression,treatment effect and prognosis.Therefore,examining the expression level of SALL4 will be of great importance in the diagnosis of disease and monitoring the disease progression for non-germ cell tumors.

关 键 词：肿瘤 诊断 肿瘤标记 生物学 婆罗双树样基因4 Sal-like 4 

分 类 号：R730.4[医药卫生—肿瘤]