结直肠腺癌转移相关基因的研究进展  

The research about the genes related with the migration of the colorectal adenocarcinoma

作　　者：熊东[1] 陈张雨 王丽军[2] 朱剑军[3] 

机构地区：[1]川北医学院临床医学系,四川南充637000 [2]川北医学院外国语言文化系,四川南充637000 [3]川北医学院基础医学院人体解剖学教研室,四川南充637000

出　　处：《生物技术世界》2016年第4期5-6,8,共3页Biotech World

基　　金：四川省教育厅基金项目(13AB0242);川北医学院科研发展计划项目(CBY12-A-QN01)

摘　　要：结直肠腺癌的发生和发展是一个涉及多基因,多步骤的复杂过程。在结直肠腺癌的发生发展过程中,癌基因被激活,或者抑癌基因被沉默,或者基因间的相互作用,最终导致结直肠腺癌的不断发展,进而导致癌症的转移与浸润。近年来研究发现,与结直肠腺癌迁移与浸润相关的的基因越来越多。但是,这些基因是如何作用,在结直肠腺癌的发病过程中是否起着重要的作用。本文就近年来与结直肠腺癌迁移与浸润相关的基因,例如:RUNX3、TGF-β1、MACC1、MMP-2、MMP-7等展开综述。The development process of the colorectal adenocarcinoma is a multi-process related with multi-genes and multi-steps. The oncogenes areactivated, or the suppressor oncogenes are silenced, or the interaction among the genes, which leads to the development of the colorectal adenocarcinoma, thenresulting in the the migration and invasion of the cancer, during the genesis and development process of the colorectal adenocarcinoma. Recently, lots of thestudy showed that there are many genes which are related with the migration and invasion of the colorectal adenocarcinoma. However, how about the functionsof the genes, and whether they play important roles in the processes So we sum some genes, such as, RUNX3 、TGF-β1、MACC1、MMP-2、MMP-7, etal, to discuss their functions in the development process of the colorectal adenocarcinoma in this paper.

关 键 词：结直肠腺癌基因发展 

分 类 号：R735[医药卫生—肿瘤]