鼠双微体2与核糖体蛋白L23在胃癌组织中的表达及临床意义  

Clinical significance of expression of murine double minute 2 and ribosomal protein L23 in gastric cancer

作　　者：蒋雨薇[1,2] 张志敏[1] 冯俊明[3] 张鹏[3] 杨波[1] 赵勇[1] 王伟星[1] 章必成[1] 饶智国[1] 

机构地区：[1]广州军区武汉总医院肿瘤科,湖北省武汉市430070 [2]湖北中医药大学临床医学院,湖北省武汉市430065 [3]广州军区武汉总医院病理科,湖北省武汉市430070

出　　处：《世界华人消化杂志》2016年第4期513-520,共8页World Chinese Journal of Digestology

基　　金：湖北省自然科学基金资助项目;No.2014FC1049~~

摘　　要：目的:研究胃癌中鼠双微体2(murine double mimute 2,MDM2)与核糖体蛋白L23(ribosomal protein L23,RPL23)的表达及其临床相关性,初步探讨他们在胃癌发生发展中的生物学意义.方法:采用免疫组织化学染色方法检测90例胃癌组织和30例胃癌旁正常组织中MDM2和RPL23蛋白的表达;统计学分析他们表达的相关性及其与临床病理因素、患者生存时间的联系.结果:胃癌组织中MDM2表达阳性率与癌旁对照组比较显著性增高(62.2%vs 40.0%,P<0.05),而RPL23蛋白表达显著性降低(30.0%vs 63.3%,P<0.05).MDM2和RPL23在胃癌中的表达呈负相关(r=-0.23,P=0.029).多因素分析显示MDM2高表达和RPL23低表达、淋巴结转移、肿瘤入侵深度、肿瘤的大小对胃癌患者生存预后的影响有统计学意义.结论:MDM2、RPL23的表达与胃癌的发生发展具有一定的相关性,针对两者的信号通路或许可作为胃癌预后的标志和新型治疗靶标.AIM： To detect the expression of murine double minute 2 （MDM2） and ribosomal protein L23 （RPL23） in gastric cancer and explore their biological significance in the development of gastric cancer. METHODS： The expression of MDM2 and RPL23 was detected by immunohistochemistry in 90 human gastric carcinoma specimens and 30 normal gastric tissue specimens. The correlation of MDM2 and RPL23 expression with the clinicopathologic features of gastric carcinoma was analyzed statistically. RESULTS： The positive expression rate of MDM2 in gastric cancer tissues was significantly higher than that in the control group （62.2% vs 40%, P 〈 0,05）, while the positive rate of RPL23 expression was significantly lower in gastric cancer tissues （30% vs 63.3%, P 〈 0.05）.The expression of MDM2 and RPL23 in gastric cancer was negatively correlated （r = -0.23, P --- 0.029）. Multivariate analysis showed that overexpression of MDM2, low expression of RPL23, lymph node metastasis, depth of invasion and tumor size were significant prognostic factors. CONCLUSION： MDM2 and RPL23 expression may be associated with the development of gastric cancer, and they may be used as prognostic markers and new therapeutic targets in gastric cancer.

关 键 词：胃癌 鼠双微体2 核糖体蛋白L23 临床病理特征 生存分析 

分 类 号：R735.2[医药卫生—肿瘤]