大黄双途径使用在急性胰腺炎治疗中的意义  

Clinical effects of double routes of administration of rhubarb in treatment of acute pancreatitis

作　　者：俞蕾敏[1] 陈锦龙[1] 吕宾[2] 

机构地区：[1]浙江萧山医院消化内科,浙江省杭州市311202 [2]浙江中医药大学附属第一医院消化内科,浙江省杭州市310006

出　　处：《世界华人消化杂志》2016年第4期607-611,共5页World Chinese Journal of Digestology

摘　　要：目的:观察大黄鼻饲灌肠联合治疗急性胰腺炎(acute pancreatitis,AP)的疗效.方法:将83例AP患者随机分为常规治疗组,大黄双途径+常规治疗组、大黄鼻饲+常规治疗组.观察3组患者住院费用、住院时间、肠道功能恢复时间、Ranson评分、CT分级,检测血浆降钙素原(plasma calcitonin,PCT)、C反应蛋白(C-reactive protein,CRP),并进行比较.结果:3组患者无1例死亡,大黄双途径+常规治疗组患者的肠道功能恢复时间、平均住院天数和住院费用均低于其他两组(与常规治疗组比,P<0.05;与大黄鼻饲+常规治疗组比,P<0.05).治疗1 wk后,CT分级、CRP、PCT明显下降(P<0.05).结论:大黄双途径联合治疗AP,能促进患者肠道功能恢复,降低炎症反应,缩短住院时间,减少医疗费用,改善预后.AIM： To observe the clinical effects of adminis- tration of rhubarb by both nasal feeding and enema in the treatment of acute pancreatitis （AP）. METHODS： Eighty-three AP patients were randomly divided into three groups： A, B and C. Group A was given conventional treatment, group B was additionally administered with rhubarb by both nasal feeding and enema on the basis of conventional therapy, and group C was additionally administered with rhubarb by nasal feeding on the basis of conventional therapy. Hospitalization costs, hospitalization time, time to recovery of intestinal function, Ranson score, CT classification, plasma calcitonin （PCT） and C reactive protein （CRP） were compared for the three groups. RESULTS： In all the three groups, no patients died. Time to intestinal function recovery, average length of hospital stay and hospitalization costs were significantly lower in group B than in the other two groups （P 〈 0.05 for all）. After one week of treatment, CT grade, CRP and PCT were significantly decreased （P 〈 0.05）. CONCLUSION： Double routes of administration of rhubarb in AP patients can promote the recovery of intestinal function, reduce the inflammatory response, shorten the length of hospital stay, reduce medical costs, and improve prognosis.

关 键 词：大黄 双途径治疗 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]