RegⅣ和HIP在胃肠道腺癌中的表达及临床意义  

Expression and Clinical Significance of the Regenerating Gene Ⅳ and HIP in Gastrointestinal Adenocarcinoma

作　　者：康晓芳[1,2] 齐凤杰[1] 

机构地区：[1]辽宁医学院附属第一医院病理学教研室,辽宁锦州121000 [2]锦州市第二医院呼吸消化内科,辽宁锦州121000

出　　处：《医学与哲学（B）》2016年第1期70-73,共4页Medicine & Philosophy(B)

摘　　要：研究再生基因4(RegⅣ)和肝细胞癌-肠-胰腺中表达的基因(HIP)在胃肠道腺癌中的表达及其临床意义。构建微阵列组织芯片,应用免疫组织化学技术检测胃肠道腺癌及其相应的癌旁组织中RegⅣ和HIP的表达。结果显示,与对照组相比,RegⅣ的表达显著下降,HIP的表达明显增高,差异具有统计学意义(P<0.05)。RegⅣ与HIP在胃肠道腺癌组织中的表达呈负相关,且与患者组织学分级均不相关。提示RegⅣ、HIP在胃肠道腺癌中表达具有一定关联性,可能为胃肠道腺癌治疗靶点提供重要依据。To explore the expression and clinical significance of regenerating gene 4 （RegⅣ）and hepatocellular carcinoma-intestines-pancreas （HIP） related gene in gastrointestinal adenocarcinoma. Constructing of tissue microarrays and then the expression of RegⅣ and HIP in gastrointestinal adenocarcinoma and adjacent normal tissues were studied with immunohistochemistry. Results showed that comparing with the control group, the expression of RegⅣwas remarkably decreased, while the expression of the HIP was significantly increased （P〈0.05）. The expression of RegⅣand HIP in gastrointestinal adenocarcinoma displayed negative correlation but these expression had no relation with the histological grade. It suggest that the expression of RegⅣ and HIP in gastrointestinal adenocarcinoma may have some relevance, these discovery may provide an important basis for the target therapy of the gastrointestinal adenocarcinoma.

关 键 词：RegⅣ HIP 胃肠道腺癌 免疫组织化学 组织芯片 

分 类 号：R363.1[医药卫生—病理学]