无抽搐电休克对精神分裂症患者血清脑源性神经营养因子的影响  

Effect of modified electroconvulsive therapy on serum brain-derived neurotrophic factor in schizophrenic patients

作　　者：肖文焕[1] 李金[1] 张晓斌[1] 唐小伟[1] 沙维伟[1] 乔云飞[2] 

机构地区：[1]扬州大学医学院附属五台山医院,扬州225009 [2]苏北人民医院

出　　处：《国际精神病学杂志》2016年第1期1-3,共3页Journal Of International Psychiatry

摘　　要：目的探讨改良电抽搐治疗(MECT)对精神分裂症(SZ)患者血清脑源性神经营养因子(BDNF)的影响。方法采用酶联免疫吸附法对80例SZ患者(患者组)在MECT前后和77例正常人(正常组)进行血清BDNF水平检测,研究MECT对精神分裂症患者BDNF水平的影响。结果 MECT前,患者组血清BDNF水平[(9.7±2.1)ng/ml]显著低于正常组[(12.4±3.2)ng/ml](t=6.2,P<0.01)。MECT后,患者组血清BDNF水平[(11.9±3.3)ng/ml]显著升高,与MECT前比较有显著差异(t=-4.8,P<0.01),与正常组无显著差异(t=0.9,P>0.05)。结论 SZ患者可能存在血清BDNF水平低下,MECT可以提高患者血清BDNF水平。Objective To explore the effect of modified electroconvulsive therapy（ MECT） on serum brainderived neurotrophic factor（ BDNF） in schizophrenic patients（ SZ）. Method The serum BDNF levels were measured by enzyme-linked immunosorbent assay in 80 SZ（ patient group） before and after MECT and 77 normal controls（ normal group）. Results Before MECT,the serum BDNF levels in patient group [（ 9. 7 ± 2. 1） ng /ml]]were significantly lower than the levels in normal group [（ 12. 4 ± 3. 2） ng / ml]（ t = 6. 2,P〈0. 01）. After MECT,the serum BDNF levels are significantly increase as compare to before MECT in patient group [（ 11. 9 ± 3. 3） ng / ml]（ t =-4. 8,P〈0. 01）. Moreover,there is no significant difference between the patient group and normal group after MECT（ t = 0. 9,P〉0. 05）. Conclusion The patients maybe have lower BDNF levels and MECT can increase the serum BDNF concentrations.

关 键 词：精神分裂症 改良无抽搐电休克治疗 脑源性神经营养因子 

分 类 号：R749.3[医药卫生—神经病学与精神病学]