代谢型谷氨酸受体3基因多态性与中国北方汉族男性酒依赖关系的研究  

An association study of polymorphic GRM_3 gen with alcohol dependence in northern Han Chinese men

作　　者：付忠伍[1] 胡建[1] 唐春玲[1] 夏炎[1] 

机构地区：[1]哈尔滨医科大学附属第一医院,哈尔滨150000

出　　处：《国际精神病学杂志》2016年第1期34-37,共4页Journal Of International Psychiatry

基　　金：黑龙江省卫生厅科研课题(编号2011-022)

摘　　要：目的探讨中国北方汉族人群代谢型谷氨酸受体3(GRM3)基因多态性与酒依赖的相关性。方法采用聚合酶链反应(PCR)和连接酶检测反应(LDR)方法,检测248例酒依赖患者和235例对照组的GRM3组基因上10个位点的单核苷酸多态性。结果酒依赖组与对照组相比较,rs6465084位点的A等位基因和A/A基因型频率明显增高(P<0.05)。单体型TAATATT、CAGTATT、TCGTATT、CAATAGC、TAATATC频率在酒依赖组和对照组中具有统计学显著差异(P<0.05),其中单体型TAATATT频率较对照组明显增高(P<0.001),且频率≥5%。结论GRM3基因可能是酒依赖发生的候选基因之一。Objective To investigate the association of metabotropic glutamate receptor（ GRM3） gene polymorphic and alcohol dependence in a Han population in northern China. Methods 248 male alcohol-dependent patients and 235 male control subjects were recruited. Ten SNPs in the GRM3 region were studied. Genotyping of SNPs was done using ligase detection reactions. Results The frequency of A allele of SNP rs6465084 was greater in alcohol-dependent group than in control group. Significant differences of haplotype frequencies were observed in five combinations（ including TAATATT,CAGTATT,TCGTATT,CAATAGC,TAATATC） in the linkage disequilibrium（ LD） constructed by seven SNPs between the groups. The frequency of TAATATT haplotype was greater in alcoholic group than in control group,and higher than 5%. Conclusion GRM3 gene may be as a risk factor of alcohol dependence.

关 键 词：代谢型谷氨酸受体3 单核苷酸多态性 酒依赖 

分 类 号：R749[医药卫生—神经病学与精神病学]