亚甲基四氢叶酸还原酶基因多态性与癌症研究进展  

Research progress on methylenetetrahydrofolate reductase polymorphism and cancer

作　　者：邹小娟[1] 丁卓伶[1] 张标[1] 杨远荣[1] 

机构地区：[1]华中科技大学同济医学院附属荆州医院药剂科,荆州434000

出　　处：《新医学》2016年第2期76-79,共4页Journal of New Medicine

摘　　要：亚甲基四氢叶酸还原酶(MTHFR)是一个多形态的酶,参与叶酸的代谢。到目前为止,MTHFR 677TT基因多态性已经被报道与多种癌症相关,但许多研究结果仍存在争议。该文就MTHFR基因多态性与乳腺癌、前列腺癌、结肠癌、食管腺癌、肺癌相关性的研究进展做一综述,分析MTHFR基因多态性是否为癌症的易感因素,为更进一步的深入研究提供依据。Methylenetetrahydrofolate reductase（ MTHFR） is a polymorphous enzyme,which is involved in the metabolism of folate acid. Up to date,it has been reported that MTHFR polymorphism is correlated with multiple carcinomas. However,relevant research findings remain debatable. This article aims to summarize the research progress on the association between MTHFR polymorphism and varying cancers including breast cancer,prostate cancer,rectal cancer,esophageal cancer and lung cancer. We try to analyze whether MTHFR polymorphism is a susceptibility factor for the incidence of cancer and provide consolidate evidence for subsequent investigation.

关 键 词：亚甲基四氢叶酸还原酶 基因多态性 癌症 

分 类 号：R730.2[医药卫生—肿瘤]