血清PG、CA72-4和TK1对胃癌筛查及诊断价值的研究  

Study on the screening and diagnostic value of serum pegsinogens,CA72- 4 and TK1 for gastric cancer

作　　者：何燕霞[1] 王凯[1] 巩姣梅[2] 崔会玲[2] 任艳萍[2] 王燕[2] 

机构地区：[1]郑州大学第三附属医院检验科,河南郑州450052 [2]郑州大学第二附属医院检验科,河南郑州450014

出　　处：《中国卫生检验杂志》2016年第2期240-243,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨CA72-4、TK1、PGⅠ、PGR对胃癌筛查及诊断的价值。方法以健康体检者100例,非萎缩性胃炎患者101例,萎缩性胃炎患者59例,胃溃疡患者40例,胃癌患者52例作为研究对象。采用电化学发光法检测血清CA72-4,用酶联免疫法检测血清TK1,用乳胶增强免疫比浊法检测血清PGⅠ和PGⅡ,并计算PGR。结果胃癌组CA72-4和TK1明显上升,而PGⅠ和PGR明显下降。联合指标检测时ROC曲线下面积为0.904,CA72-4、TK1、PGⅠ、PGR4种指标分别检测时的ROC曲线下面积分别为0.681、0.801、0.742和0.779。取最佳诊断临界值时,联合检测时的敏感度为88.5%,高于单项检测时的敏感度。结论血清PGⅠ和PGR检测对萎缩性胃炎、胃溃疡和胃癌的诊断有重要价值,同时联合检测CA72-4和TK1可提高胃癌诊断敏感度。联合检测对胃癌的筛查和诊断有重要意义。Objective To investigate the screening and early diagnostic value of serum CA72- 4,TK1,PGⅠand PGR for gastric cancer. Methods The study enrolled 100 healthy people,101 patients with chronic non- atrophic gastritis,59 patients with chronic atrophic gastritis,40 patients with gastric ulcer and 52 patient with gastric cancer. CA72- 4 was measured by electrochemiluminescence（ ELC）. TK1 was measured by ELISA. The levels of PGⅠand PGⅡwere measured by latex- enhanced immunoturbidimetry,at the same time PGR was calculated. Results Compared with the other four groups,the level of CA72- 4 and TK1 in GC group increased significantly,however,PGⅠand PGR decreased significantly. The area under curve of ROC was 0. 904 with the combined detection of markers. The area under curve of ROC was 0. 681,0. 801,0. 742 and 0. 779 respectively under the single detection of the 4 markers. With the help of optimal cut- off values,the sensitivity was 88. 5%when the the four markers were combined,which was higher than that of the single detection. Conclusion Serum PGⅠand PGR have important value for the diagnostic of chronic atrophic gastritis,gastric ulcer and gastric cancer. The combined detection of CA72- 4 and TK1 can improve the diagnostic sensitivity of gastric cancer. There is great significance for the screening and diagnostic of gastric cancer with the combined detection of the four markers.

关 键 词：胃癌 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ 糖类抗原72-4 细胞质胸苷激酶1 

分 类 号：R735.2[医药卫生—肿瘤]