冠心病患者血清碱性磷酸酶与冠状动脉狭窄程度的关系研究  

Relationship between the serum alkaline phosphatase level and the severity of coronary artery stenosis in patients with coronary heart disease

作　　者：唐恩燕[1] 徐克[1] 朱苑芳 施中平[1] 唐少华[1] 

机构地区：[1]温州医科大学定理临床学院检验科,325000 [2]温州医科大学定理临床学院心内科,325000

出　　处：《心电与循环》2016年第1期32-34,共3页Journal of Electrocardiology and Circulation

摘　　要：目的探讨冠心病患者血清碱性磷酸酶（ALP）水平与冠状动脉狭窄严重程度的关系。方法回顾性分析470例冠心病住院患者的临床资料，血清碱性磷酸酶（ALP）水平男＞129 U/L，女＞104 U/L被定义为ALP升高。按照Gensini评分判断冠状动脉狭窄程度，Gensini评分＞40分定义为严重狭窄。对狭窄相关的因素进行多变量logistic回归分析。结果冠状动脉严重狭窄组329例，非严重狭窄组141例。冠状动脉严重狭窄组血清ALP水平（105.4±60.7）U/L，较非严重狭窄组[（78.4±38.7）U/L]高，两组ALP水平升高比例（22.0%、5.0%）差异有统计学意义（P＜0.01）。多变量logistic回归分析提示， ALP水平升高是冠状动脉狭窄的独立影响因素（OR 1.013，95%CI 1.003~1.023，P＜0.05）。结论 ALP水平升高可能与冠状动脉狭窄有关。Objective To investigate the relationship between serum ALP levels and the severity of coronary stenosis in patients with coronary heart disease （CHD）. Methods Clinical data were analyzed retrospectively in 470 inpatients with CHD. Serum ALP levels〉129 U/L in men and〉104 U/L in women were defined as elevated. Gensini score was used to evaluate coronary artery stenosis and greater than 40 means significant coronary artery stenosis. Multivariable logistic regression analysis was performed to analyze factors related to coronary stenosis. Results 329 patients had significant coronary artery stenosis and 114 patients had non- significant coronary artery stenosis. ALP levels （105.4±60.7 vs.78.4± 38.7 U/L, P〈0.01） and the percent of patients with elevated ALP levels （22.0 vs. 5.0%, P〈0.01） were significantly higher in patients with significant coronary stenosis than with non- significant coronary stenosis. Regression analysis showed serum ALP elevation was an independent factor associated with coronary stenosis （OR 1.013, 95% CI 1.003~1.023, P〈0.05）. Conclusion The elevated ALP level maybe associated with coronary artery stenosis.

关 键 词：碱性磷酸酶 冠心病 GENSINI评分 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]