血清C反应蛋白联合红细胞压积对重症急性胰腺炎的早期预测价值  

Role of C Reactive Protein Combined with Hematocrit in Early Prediction of Severe Acute Pancreatitis

作　　者：陈润浩[1] 张斌[2] 李小燕[1] 张华云[1] 孙培龙[1] 俞建平[1] 

机构地区：[1]复旦大学附属金山医院普外科,上海201508 [2]复旦大学附属金山医院检验科,上海201508

出　　处：《中国临床医学》2015年第6期715-717,共3页Chinese Journal of Clinical Medicine

基　　金：上海市金山区科学技术委员会课题(编号:2011-3-03)

摘　　要：目的:探讨血清C反应蛋白(CRP)联合红细胞压积(Hct)检测用于早期预测重症急性胰腺炎(SAP)的临床价值。方法:选择2011年4月—2014年12月因急性胰腺炎住院治疗的患者75例,比较轻症急性胰腺炎(MAP)和SAP患者入院24 h内CRP和Hct的差异,建立受试者工作特征(ROC)曲线,评估早期CRP、Hct单项检测及两者联合检测对SAP的诊断效率。结果:SAP组患者的CRP和Hct水平均明显高于MAP组,差异有统计学意义(P<0.05)。CRP和Hct诊断SAP的敏感性分别为61.56%、49.57%,特异性分别为83.27%、80.23%,阳性预测值分别为53.52%、40.35%,阴性预测值分别为90.37%、85.26%。CRP联合Hct诊断SAP的敏感性为51.23%,特异性为94.29%,阳性预测值为76.12%,阴性预测值为87.23%。结论:CRP联合Hct有助于急性胰腺炎严重程度的早期诊断,具有一定的临床应用价值。Objective ：To explore the clinical value of serum C reactive protein （CRP） combined with hematocrit （Hct） in prediction of severe acute pancreatitis（SAP） .Methods ：Seventy five patients ,who were admitted due to AP during April 2011 and December 2014 ,were enrolled .The levels of CRP and Hct ,which were determined within 24 h after admission ,were compared between the patients with SAP and those with mild acute pancreatitis （MAP） .The diagnostic efficiency of CRP combined with Hct in early prediction of SAP was evaluated by ROC curve .Results ： The levels of CRP and Hct in SAP group were significantly higher than those in MAP group （P〈 0 .05） .The sensitivities of CRP and Hct in the diagnosis of SAP were 61 .56% and 49 .57% ,respectively . The specificities were 83 .27% and 80 .23% ,respectively . And the positive predictive values were 53 .52% and 40 .35% ,respectively .Furthermore ,the negative predictive values were 90 .37% and 85 .26% , respectively .The sensitivity of CRP combined with Hct in diagnosis of SAP was 51 .23% .The specificity was 94 .29% .And the positive predictive value was 76 .12% . Furthermore , the negative predictive value was 87 .23% . Conclusions ： CRP combined with Hct is conducive to early diagnosis of the severity of AP .Thus ,it is worthy of clinical practice .

关 键 词：C反应蛋白 红细胞压积 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]