肺癌患者外周血淋巴细胞亚群数量低下相关因素分析  

Analysis of related factors of low lymphocyte subpopulations in peripheral blood of lung cancer patients

作　　者：方可欣[1] 续力云[1] 陈冬冬[1] 陆畅畅 刘晓光[1] 乐涵波[1] 张永奎[1] 

机构地区：[1]浙江省舟山医院,浙江省舟山316021

出　　处：《中华航海医学与高气压医学杂志》2015年第6期462-466,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：浙江省重大科技专项重点项目（2012C13015-3）

摘　　要：目的：探讨肺癌患者外周血淋巴细胞亚群数量低下相关因素。方法收集216例海岛居民肺癌患者性别、年龄、吸烟史、有无淋巴结转移、肿瘤大小、癌胚抗原（ CEA ）水平、肿瘤分期、肺癌组织学类型等资料。应用流式细胞仪分析外周血CD3^＋T 细胞、CD4^＋T细胞、CD8＋T细胞、NK细胞百分比。结果与在正常参考值范围或高于上限组比较，CD3^＋T细胞比例低于参考值范围下限组年龄≥60岁患者有30例，占所有年龄≥60岁患者（18例）的25．42％，而年龄＜60岁的患者有14例，占该年龄段（98例）的31．82％，T1期和T2期患者为39例，占该分组（205例）的19．02％，T3期和T4期患者为5例，占该分组（11例）的45．45％；腺癌患者为28例，占该分组（149例）的18．79％，鳞癌患者为15例，占该分组（57例）的26．32％，差异有统计学意义（P＜0．05）；在CD8＋T细胞比例低于参考值范围下限组中，鳞癌7例，占12．28％，腺癌9例，占6．04％，差异有统计学意义（P＜0．05）；在NK细胞比例低于下限组中，有淋巴结转移10例，占25．00％（40／110），无淋巴结转移22例（22／176），占12．5％，差异有统计学意义（P＜0．05）。结论肺癌免疫力低下与患者年龄、肺癌较晚分期、鳞癌、淋巴结转移密切相关。Objective To investigate related factors of low lymphocyte subpopulations in peripheral blood of lung cancer patients.Methods Medical data, such as gender, age, smoking history, lymphatic metastasis, tumor size, CEA level, tumor stage and histology, were collected in 216 cases of lung cancer.The percentages of CD 3 ＋T cells, CD4 ＋T cells, CD8 ＋T cells and NK cells were analyzed by flow cytometry . Results When compared with that of the normal reference data and that of the above upper limit group , the proportion of CD 3 ＋T cells was lower than that of the lower reference limit group .There were 30 patients with an age ≥60 years, accounting for 25.42% of that age group, while there were 14 patients with an age 〈60 years, accounting for 31.82%of that age group .Statistical differences could be noted , when comparisons were made between the 2 groups（P 〈0.05）.There were 39 stage -T1 and stage -T2 patients, accounting for 19.02%of that age group , and there were 11 stage-T3 and stage-T4 patients, accounting for 45.45%of that age group.And statistical differences could be noted , when comparisons were made between the 2 groups（P〈0.034）.There were 28 patients with adenocarcinoma, accounting for 18.79% of that age group, and there were 15 patients with squamous cell carcinoma , accounting for 26.32% of that age group, and statistical differences could be seen, when comparisons were made between the 2 groups（P〈0.05）.The proportion of CD8 ＋T cells was lower than that of the lower reference limit group .There were 7 patients with squamous cell＆amp;nbsp;carcinoma, accounting for 12.28% of that age group, while there were 9 patients with adenocarcinoma, accounting for 6.04%of that age group, and statistical differences could be noticed , when comparisons were made between the 2 groups（P〈0.042）.In the patients with the proportion of NK cells lower than that of the lower limit group, there were 10 patients with lymphatic metastasis , accounting for 25.00%, and there were 22 patients with

关 键 词：肺癌 淋巴细胞亚群 肿瘤分期 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]