多西紫杉醇修饰的人工晶体与眼组织相容性分析  

Bio-compatibility of Intraocular Lens Modified by Docetaxel to Ocular Tissues

作　　者：李博[1,2] 乐江[1] 章剑[2] 陈金鹏[2] 张鹏[2] 

机构地区：[1]武汉大学基础医学院,湖北武汉430071 [2]湖北省鄂州市中心医院眼科,湖北鄂州436000

出　　处：《现代生物医学进展》2015年第35期6935-6937,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨经多西紫杉醇修饰的人工晶体对眼组织相容性的影响。方法:按照随机数字表法将32只日本大耳兔分为两组:实验组通过手术植入表面经多西紫杉醇修饰处理后的疏水性人工晶体,对照组植入疏水性人工晶体。比较两组人工晶体亲水角、术后24小时光耀斑块计数以及人工晶体周围组织炎症浸润数。结果:实验组的亲水角小于对照组,差异有统计学意义(P<0.05)。实验组光耀斑块计数低于对照组,差异有统计学意义(P<0.05)。实验组家兔人工晶体周围组织炎症浸润计数低于对照组,差异有统计学意义(P<0.05)。结论:人工晶体表面经多西紫杉醇修饰后,其亲水性、与眼组织的组织相容性增加,且可缓解光耀斑炎症感染和降低并发症的发生,有重要的临床参考价值。Objective： To explore the bio-compatibility influence ofintraocular lens modified by docetaxel to ocular tissues. Methods： A total of 32 Japanese rabbits were randomly divided into experimental group and control group. The experimental group was surgically implanted hydrophobic intraocular lens modified by docetaxel, while the control group, hydrophobic intraocular lens only. The hy-drophilic angle, flare spot and the number of inflammatory infiltration surrounding ocular tissues 24 h after operation of the two groups were compared. Results： The hydrophilic angle in the experimental group was smaller than that in the control group, the difference was statistically significant（P〈0.05）. The number of flare spot in the experimental group was less than that in the control group, the difference was statistically significant （P〈0.05）. The number of inflammatory infiltration surrounding ocular tissues in the experimental group was less than that in the control group, the difference was statistically significant（P〈0.05）. Conclusion： Intraocular lens modified by docetaxel has a better hydrophilicity and bio-compatibility with ocular tissue. It can relieve the inflammation infection of flare spot and reduce the incidence of complications, which is worthy of clinical reference.

关 键 词：多西紫杉醇 人工晶体 眼组织 组织相容性 

分 类 号：R776[医药卫生—眼科]