维生素D对神经发育的影响及其与精神分裂症的关系  

The effects of vitamin D on brain development and its implications for schizophrenia

作　　者：党瑞丽[1] 郭玉金[1] 蔡骅琳[2] 朱运贵[2] 江沛[1] 

机构地区：[1]济宁市第一人民医院临床药学科,山东省272000 [2]中南大学湘雅二医院临床药学研究室,长沙410001

出　　处：《中华脑科疾病与康复杂志（电子版）》2015年第6期62-65,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：国家自然科学基金青年基金项目(81401113)

摘　　要：近年来,维生素D的生理作用已从传统的调节体内钙、磷及骨代谢平衡延伸到参与影响机体免疫、内分泌、心血管及神经系统等多种重要的生理功能。精神分裂症的神经发育假说认为神经发育障碍可能是导致精神分裂症的重要原因。而越来越多的研究证据表明维生素D作为新型神经活性甾体能够通过调节神经营养因子表达、多巴胺(DA)神经传递系统、细胞内钙平衡、活性氧及与神经元分化、结构和能量代谢相关的基因、蛋白的表达等多种途径影响神经系统正常的发育和功能。流行病学及临床前研究表明生命早期的维生素D缺乏可能是包括精神分裂症在内的多种神经精神疾病的危险因素。本文就近年来维生素D对神经发育的影响及其与精神分裂症的关系的研究进展进行综述。The role of vitamin D in calcium-phosphorus homeostasis and bone health has been known for over a century. Over the last decade, emerging evidence has suggested that vitamin D may play a role in immune, endocrine, cardiovascular and central nervous systems. Based on the neurodevelopmental hypothesis, schizophrenia is considered as a neurodevelopmental disorder. Multiple lines of evidence suggest that vitamin D is actually a neuroactive steroid that could affect the developing brain including its effects on neurotrophic factor expression, dopamine （ DA ） neurotransmitter system, intracellular calcium signaling, regulation of reactive oxygen species and the expression of genes/proteins involved in neuronal differentiation, structure and metabolism. Early deficiencies have been linked with neuropsychiatric disorders, including schizophrenia. This review provided a concise summary of the recent evidence implicating a role for vitamin D in the developing brain and its potential link with schizophrenia.

关 键 词：精神分裂症 维生素D 多巴胺 神经发育 

分 类 号：R749.3[医药卫生—神经病学与精神病学]