乌司他丁对62例食管癌患者术后应激和炎症反应的影响  

Effect of Ulinastatin on Postoperative Stress and Inflammatory Reaction of 62 Patients with Esophageal Cancer

作　　者：周仕彬 黄伟[1] 叶伟[1] 徐丹[1] 庞波[1] 

机构地区：[1]四川省乐山市人民医院麻醉科,四川乐山614000

出　　处：《现代生物医学进展》2015年第36期7104-7106,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30672193)

摘　　要：目的:观察乌司他丁对食管癌患者术后应激和炎症反应的影响。方法:选择我院2014年1月至2015年3月接受手术治疗的食管癌患者124例,随机分为两组,每组62例。观察组术后给予乌司他丁治疗,对照组仅接受常规抗感染治疗。观察并比较两组患者手术后应激反应和炎性因子的变化情况。结果:术后3d两组NE、E、Cor、TNF-α、IL-6、IL-8水平均较术前明显升高(P<0.05)。对照组NE、E、Cor、TNF-α、IL-6、IL-8水平升高幅度明显大于观察组,两组比较差异具有统计学意义(P<0.05)。观察组并发症发生率为8.06%,对照组并发症发生率为19.35%,两组并发症发生率比较差异具有统计学意义(P<0.05)。结论:食管癌患者行开胸切除术可引起全身炎症反应,乌司他丁的应用可抑制术后炎症因子的释放,减轻术后应激,对降低并发症的发生率,促进康复具有积极的作用。Objective： To observe the effects of ulinastatin on the stress and inflammatory reactions of patients with esophageal cancer after resection. Methods： 124 patients with esophageal cancer undergoing radical surgery in Department of Thoracic Surgery of our hospital from January 2014 to March 2015 were collected and randomly divided into the observation group and the control group,with 62 cases in each group. The patients in the observation group were treated with ulinastatin the day after the surgery, while the patients in the control group were treated with the regular anti-infectious methods. Then the changes of stress and inflammatory factors in the two groups before and after the operation were compared. Results： The levels of NE, E, Cor, TNF-α, IL-6 and IL-8 of the two groups3 d after the surgery were significantly higher compared with those before the surgery（P〈0.05）. The increase in control group was obviously higher than that in the observation group, and the difference was statistically significant（P〈0.05）. The occurrence rate of complication in observation group and control group was 8.06% and 19.35%, respectively, and the difference was statistically significant（P〈0.05）. Conclusion： Thoracotomy resection in esophageal carcinoma patients can cause systemic inflammatory response, and the application of ulinastatin can inhibit the postoperative release of inflammatory factors and reduce the postoperative stress, which plays a positive role in reducing the occurrence rate of complication and promoting rehabilitation.

关 键 词：乌司他丁 食管癌 术后应激 炎症反应 影响 

分 类 号：R735.1[医药卫生—肿瘤]