Histone modifications in DNA damage response  

作　　者：Lin-Lin Cao Changchun Shen Wei-Guo Zhu 

机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and BiomimeticDrugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China [2]Peking University-Tsinghua University Joint Center for Life Sciences, Beijing 100084, China [3]Shenzhen University School of Medicine, Shenzhen 518060, China [4]Department of Clinical Laboratory Peking University People's Hospital, Beijing 100044, China

出　　处：《Science China(Life Sciences)》2016年第3期257-270,共14页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(81321003;91319302;31070691);Ministry of Science and Technology of China(2011CB504200);Ministry of Education of China(111 project);Peking University-Tsinghua University Center for Life Science

摘　　要：DNA damage is a relatively common event in eukaryotic cell and may lead to genetic mutation and even cancer. DNA damage induces cellular responses that enable the cell either to repair the damaged DNA or cope with the damage in an appropriate way. Histone proteins are also the fundamental building blocks of eukaryotic chromatin besides DNA, and many types of post-translational modifications often occur on tails of histones. Although the function of these modifications has remained elusive, there is ever-growing studies suggest that histone modifications play vital roles in several chromatin-based processes, such as DNA damage response. In this review, we will discuss the main histone modifications, and their functions in DNA damage response.DNA damage is a relatively common event in eukaryotic cell and may lead to genetic mutation and even cancer. DNA damage induces cellular responses that enable the cell either to repair the damaged DNA or cope with the damage in an appropriate way. Histone proteins are also the fundamental building blocks of eukaryotic chromatin besides DNA, and many types of post-translational modifications often occur on tails of histones. Although the function of these modifications has remained elusive, there is ever-growing studies suggest that histone modifications play vital roles in several chromatin-based processes, such as DNA damage response. In this review, we will discuss the main histone modifications, and their functions in DNA damage response.

关 键 词：DNA damage response histone modifications CHROMATIN DNA repair 

分 类 号：Q75[生物学—分子生物学]