急性缺血性脑卒中患者尿微量清蛋白与尿肌酐比值对近期神经功能恢复的影响  

The influence of urinary albumin to urinary creatinine ratio of patients with acute ischemic stroke on the recovery of nerve function

作　　者：胡明珠[1] 黄天清 向明湘 

机构地区：[1]吉首市人民医院内科 [2]湘西自治州人民医院神经内科,湖南吉首416000

出　　处：《川北医学院学报》2016年第1期94-96,共3页Journal of North Sichuan Medical College

摘　　要：目的:检测急性缺血性脑卒中患者尿微量清蛋白与尿肌酐比值(albumin and urinary creatinine ratio,ACR),分析其对患者近期神经功能恢复的影响,为患者的临床治疗及预后的评估提供依据。方法:选择本院2014年1月至2015年4月急性缺血性脑卒中患者69例(观察组),其中NIHSS≥10分者31例,NIHSS评分<10分者38例;正常体检人群69例(对照组)。检测实验组和对照组中不同NIHSS评分患者尿液ACR值。结果:对照组ACR值为(1.60±0.62)mg/mmol,低于观察组(5.81±0.74)mg/mmol,差异具有统计学意义(P<0.05)。NIHSS评分≥10分患者的ACR值为(5.72±0.73)mg/mmol,高于NIHSS评分<10分的患者(4.19±0.50)mg/mmol,随着治疗时间的延长,实验组和对照组患者ACR值均呈下降趋势。ACR≥3 mg/mmol患者的NIHSS评分为(12.46±0.68)分,高于ACR<3 mg/mmol的患者NIHSS评分为(9.37±0.82)分,随着治疗时间的延长,实验组和对照组患者NIHSS评分均呈下降趋势。结论:急性缺血性脑卒中患者ACR值显著升高,ACR可作为急性缺血性卒中神经功能恢复的指标之一。Objective： To detect of urinary albumin to urinary creatinine ratio（ ACR） of patients with acute ischemic stroke,analyze its influence on the recovery of neurological function of the patients andprovide the basis for clinical treatment and prognosis evaluation of patients. Methods： 69 patients with acute ischemic stroke（ observation group） were selected in the hospital from January in2014 to April in 2015,which were 31 patients of NIHSS≥10,38 cases of NIHSS score 10. 69 cases of normal people were selected as the control group. Concentration of ACR in the observation group and the control group were detected. Results： The concentration of ACR of the control group waslower than that of the observation group（ 1. 60 ± 0. 62 vs 5. 81 ± 0. 74,P〈 0. 05）. The ACR concentration of NIHSS≥10 score was greater than that of NIHSS of patients 10 score. And with the extension of treatment time,the concentration of ACR of two groups were decreased. NIHSS score of ACR≥3 mg / mmol of patients was higher than that of ACR 3 mg / mmol of patients. With the extension of treatment time,NIHSS score of the observation group and the control group were all decreased. Conclusion： ACR concentration of acute ischemic stroke patients increase significantly. The higher the NIHSS score is,the higher the concentration of ACR decrease gradually. And with the longer of the treatment time,patient nerve function damage of high ACR concentration is greater. So,urine ACR can be used as one of the indexes of acute ischemic stroke neurological function recovery.

关 键 词：急性缺血性脑卒中 尿微量清蛋白与尿肌酐比值 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]