USP7蛋白与肿瘤的关系的研究进展  

Advances in the study of the relationship between USP7 protein and tumor

作　　者：周芨[1] 邓世山[2] 刘海[1] 

机构地区：[1]川北医学院附属医院耳鼻喉科 [2]川北医学院基础医学院,四川南充637000

出　　处：《川北医学院学报》2016年第1期130-135,共6页Journal of North Sichuan Medical College

基　　金：四川省科技厅项目(2010SZ0295)

摘　　要：泛素特异性蛋白酶7(ubiquitin-specific protease 7,USP7),也称为疱疹病毒属伴随的泛素特异性的蛋白酶(herpesvirus-associated ubiquitin specific protease,HAUSP),是泛素特异性修饰酶家族(ubiquitin specific processing enzymes,UBPs)的成员之一。USP7蛋白作为一个去泛素化蛋白酶,对卷入细胞周期、癌基因和抑癌基因等相关蛋白具有重要的调控作用。所以,USP7是一个极具前景的抗癌靶点。本文拟就USP7蛋白与肿瘤的关系的研究进展进行综述。Ubiquitin-specific protease 7（ USP7）,which is also known as herpesvirus-associated ubiquitin specific protease（ HAUSP）,is one of members of ubiquitin specific processing enzymes（ USPs）. The USP7 as a deubiquitinating enzyme has an important role in regulating many proteins involved in the cell cycle,as well as oncogenes and tumor suppressors. Thus,USP7 offers a promising anti-tumor target. We review herein topics related to the relationship of this protein and cancer.

关 键 词：USP7基因 泛素 癌基因 肿瘤 

分 类 号：R394[医药卫生—医学遗传学]