甲泼尼龙冲击治疗急性脊髓炎的临床疗效分析  

Analysis of the clinical effect of methylprednisolone in the treatment of patients with acute myelitis

作　　者：王灵红[1] 黄桔秀[1] 李玉平[1] 金礼通[1] 

机构地区：[1]台州市中心医院急诊科,浙江省台州318000

出　　处：《中国基层医药》2016年第3期397-399,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨甲泼尼龙冲击治疗急性脊髓炎的临床疗效及不良反应。方法选取急性脊髓炎患者42例，采用数字表法将患者随机分为两组，每组21例。观察组进行甲泼尼龙冲击治疗，对照组进行地塞米松治疗。治疗结束后对两组患者的临床疗效及并发症进行分析。结果观察组总有效率为85．7％，明显高于对照组的42．9％（x2=2．41，P〈0．05）。观察组肌力改善、排尿恢复、自行行走时间分别为（10．1±4．1）d、（7．1±3．4）d、（16．1±4．2）d，均优于对照组的（23．4±7．3）d、（10．2±3．1）d、（22．6±7．3）d（t=3．15、1．69、1．97，均P〈0．05）。观察组不良反应总发生率为4．8％，低于对照组的19．0％（x。=6．37，P〈0．05）。结论在治疗急性脊髓炎时，采用甲泼尼龙冲击治疗的方法临床疗效显著且不良反应，应在临床推广使用。使得更多患者得到更为良好的治疗，从而提高患者治疗后的生活质量。Objective To study the clinical curative effect and complication of methylprednisolone in the treatment of patients with acute myelitis. Methods 42 patients with acute myelitis were selected and randomly divided into two groups,21 cases in each group. The control group was treated with dexamethasone, the observation group was treated with methylprednisolone. After treatment, the clinical parameters and effect of the two groups were compared. Results The total effective rate of the observation group was 85.7%, which was higher than 42.9% of the control group （x2 = 2.4i ,P 〈 0.05 ）. The improvement of muscle strength, restore micturition, walk on their own time in the observation group were （10.1± 4. 1 ）d, （7.1 ± 3.4）d, （16.1 ± 4.2）d, respectively, which were better than （23.4 ± 7.3 ） d, （ 10.2 ± 3.1 ） d, （22.6 ± 7.3 ） d in the control group （ t = 3.15,1.69,1.97, all P 〈 0.05 ）. The total incidence of gastrointestinal reaction and complication rates of the observation group was 4.8% ,which was lower than 19.0% of the control group （X2 =6.37,P 〈0.05）. Conclusion In treatment of patients with acute myelitis,methyl- prednisolone has good effect,which should be used in clinical practice.

关 键 词：脊髓炎 甲泼尼龙 地塞米松 

分 类 号：R744.3[医药卫生—神经病学与精神病学]