Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives  

作　　者：Li-Yuan Zhang Bao-Lei Wang Yi-Zhou Zhan Yan Zhang Xiao Zhang Zheng-Ming Li 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University

出　　处：《Chinese Chemical Letters》2016年第1期163-167,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 21372133);‘‘111’’ Project of Ministry of Education of China (No. B06005)

摘　　要：A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR,~1H NMR,^（13）C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50 mg/m L.A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR,~1H NMR,^（13）C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50 mg/m L.

关 键 词：Triazole thione derivatives FLUORINE PIPERAZINE Mannich base Biological activity 

分 类 号：O626[理学—有机化学]