血浆胱氨酸蛋白酶抑制剂C水平与脑小血管病关系的研究  

The clinical reserch on level of plasma cystatin C in small vessel disease

作　　者：李强[1] 孙翠梅[1] 刘建强[1] 薛浩[1] 

机构地区：[1]山东省淄博市中心医院神经内科,255036

出　　处：《卒中与神经疾病》2016年第1期12-14,共3页Stroke and Nervous Diseases

摘　　要：目的探讨血浆胱氨酸蛋白酶抑制剂C(胱抑素C)水平与脑小血管病(cerebral small vessel disease,CSVD)的关系。方法选取经MRI确诊的脑小血管病患者(观察组)61例及同期MRI检查正常者(对照组)53例,采用颗粒增强免疫比浊法测定观察组和对照组胱抑素C水平,并且对胱抑素C水平与脑小血管病的相关性进行分析。结果脑小血管病患者胱抑素C水平显著高于对照组(P<0.01);进行多因素logistic回归分析显示,Cys C水平升高与CSVD的发生显著相关(OR5.978,95%CI 4.847-11.471,P<0.01)。结论 Cys C水平升高是CSVD发生的独立危险因素,可以预测CSVD发生的危险性。Objective To observe the correlation between plasma Cystatin C（Cys C）and the cerebral small vessel disease（CSVD）.Methods 61 patients with cerebral small vessel disease diagnosed by MRI and 53 healthy subjects were recruited in this study.Level of Cys C was tested by particle enhanced immune nephelometric assay.All patients were divided into four groups based on Cys C level.The relationship between plasma Cys C and small vessel disease was analyzed by logistic regression.Results Compared with healthy subjects,level of plasma Cys C was significantly higher in the patients group,and logistic regression revealed that the risk ratios for the SVD with gradually higher level of Cvs C were 1;1.27（1.08~1.52）;1.73（1.22~2.61）;2.13（1.49~3.05）.Conclusion It is suggested that high level of plasma Cys C may be a risk factor of SVD.

关 键 词：脑小血管病 小动脉硬化 胱氨酸蛋白酶抑制剂C 

分 类 号：R743[医药卫生—神经病学与精神病学]