美多巴对帕金森病患者血栓素B_2内皮素和多巴胺受体浓度的影响  

Effects of madopar on the concentrations of thromboxane-B_2,endothelin and dopamine receptors in patients with Parkinson's disease

作　　者：孙玉华[1] 

机构地区：[1]河南大学淮河医院神经内科,开封475001

出　　处：《中国实用神经疾病杂志》2016年第4期15-17,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的研究美多巴对帕金森(Parkinson’s disease,PD)患者血浆血栓素B2、内皮素和多巴胺受体浓度的影响,为探讨美多巴治疗PD的机制提供理论依据。方法测定30例PD患者美多巴治疗前后和30例健康对照者血浆中血栓素B2(thromboxane B2,TXB2)和内皮素(endothelin,ET)浓度,同时以131I-epidepride为配体,采用SPECT功能成像美多巴治疗前后患者基底节区多巴胺D2受体,分析美多巴对多巴胺系统的影响。结果 PD患者血浆中TXB2和ET的浓度均高于健康对照组,采用美多巴治疗后,PD患者血浆中TXB2和ET的浓度降低,明显低于治疗前(P<0.05)。另外,PD患者基底节区多巴胺D2受体含量与对照组相比无显著性差异,且采用美多巴治疗前后多巴胺D2受体含量虽略有变化,也无显著性差异(P>0.05)。结论美多巴治疗可降低患者血浆中TXB2和ET的含量,但对基底节区多巴胺D2受体无影响。Objective To study the effects of madopar on the concentrations of thromboxane-B2（TXB2）,endothelin（ET）and dopamine receptors in patients with Parkinson＇s disease（PD）so as to investigate the potential mechanism of madopar in the treatment of PD.Methods The plasma concentrations of TXB2 and ET were measured in 30 healthy controls and in 30 PD patients before and after the treatment of madopar.Furthermore,with the 131I-epidepride as the ligand,the SPECT functional image was used to determine the content of dopamine D2 receptors in patients＇ basal ganglia before and after madopar treatment to explore the effect of madopar on the dopamine system.Results Compared with healthy controls,PD patients had higher plasma concentrations of TXB2 and ET,which were significantly decreased after the treatment of madopar and were obviously lower than before treatment（P〈0.05）.The content of dopamine D2 receptors in the basal ganglia that there was no significant difference in PD patients and healthy controls showed little change after madopar treatment but no statistical difference.Conclusion Madopar can decrease plasma TXB2 and ET in PD patients,but have no effect on dopamine D2 receptors of the basal ganglia.

关 键 词：帕金森病 美多巴 同型半胱氨酸 多巴胺受体 血栓素B2 内皮素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]