DNA病毒介导肿瘤发生的表观遗传机制  

Epigenetic Mechanism of DNA Virus-mediated Carcinogenesis

作　　者：胡玉倩[1] 郑义[1] 宁勇[1] 郗娟[1] 谢圣高[1] 

机构地区：[1]湖北中医药大学检验学院,武汉430065

出　　处：《肿瘤防治研究》2016年第3期230-233,共4页Cancer Research on Prevention and Treatment

基　　金：湖北省自然科学基金面上项目(2014CFB372)

摘　　要：许多病毒感染可导致肿瘤发生,这些病毒虽隶属于不同种属,但其进化出的分子干扰机制却有共通之处,即靶向调控与细胞生长和增殖相关的关键蛋白。病毒和宿主之间的相互作用也发生于表观遗传水平。本文对DNA病毒导致癌症发生的表观遗传机制进行综述。Various kinds of virus could lead to carcinogenesis. Although those viruses belong to different viraceae, the molecular mechanisms they have evolved to cause tumor initiation show many similarities, which are targeting the key cellular proteins that regulate cell growth and proliferation. The interactions between virus and hosts occur at epigenetic level. This review summarizes the epigenetic mechanism of DNA virus proteins contributing to carcinogenesis.

关 键 词：病毒 表现遗传 肿瘤发生 甲基化 MIRNA 

分 类 号：R730.231.3[医药卫生—肿瘤]