胆囊切除术与肝癌发病风险的Meta分析  

Meta-analysis on Cholecystectomy and Risk of Liver Cancer

作　　者：付海峰[1] 周文波[1] 孙少华[1] 沈丰[1] 张桢[1] 胡洪生[1] 吴红伟[1] 

机构地区：[1]湖北医药学院附属东风医院肝胆胰甲状腺外科,湖北十堰442000

出　　处：《华南国防医学杂志》2016年第1期14-18,共5页Military Medical Journal of South China

基　　金：湖北省自然科学基金资助项目(2014CFB310)

摘　　要：目的系统评价胆囊切除术与肝癌发病风险的关联。方法计算机检索PubMed、Embase、Cochrane图书馆、万方、维普和中国知网数据库,收集关于胆囊切除术与肝癌发病风险关联的前瞻性队列研究,检索时间为各自建库到2014-09-24日。按照纳入排除标准进行文献筛选,并对纳入文献进行质量评价。采用Stata 11.0软件进行meta分析。结果纳入6篇文献,包含7个队列研究,涉及595 310位研究对象和1206例肝癌患者。Meta分析结果显示：与未接受胆囊切除术者相比,接收过胆囊切除术的患者具有更高的肝癌发病风险（RR=1.48,95%CI：1.11-1.97）。结论胆囊切除术能够增加肝癌发病风险,但由于纳入研究数量有限,尚需更多高质量的前瞻性队列研究加以验证。Objective To systematically evaluate the association between cholecystectomy and the risk of liver cancer.Methods PubMed,Embase,the Cochrane Library,Chinese National Knowledge Infrastructure（CNKI）and WanFang Data were searched from their establishment to September 24,2014,to include prospective cohort studies on the association between cholecystectomy and risk of liver cancer.The literatures were selected according to the inclusion and exclusion criteria and assessed the quality of included studies.Meta-analysis was performed by using Stata 11.0 software.Results Six literatures including 7 prospective cohort studies were included for analysis,a total of 595 310 participants involved and 1206 liver cancer cases.Compared with those participants with a history of cholecystectomy had higher risk of liver cancer than those without cholecystectomy（RR=1.48,95%CI：1.11- 1.97）.Conclusion Cholecystectomy is associated with increased risk of liver cancer.Further studies are warranted considering the limited number of included studies.

关 键 词：肝癌 胆囊切除术 META分析 

分 类 号：R735.7[医药卫生—肿瘤]